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Mapping of the fibrinogen-binding site on the staphylocoagulase C-terminal repeat region

Fibrin (Fbn) deposits are a hallmark of staphylocoagulase (SC)-positive endocarditis. Binding of the N terminus of Staphylococcus aureus SC to host prothrombin triggers formation of an active SC·prothrombin∗ complex that cleaves host fibrinogen to Fbn. In addition, the C-terminal domain of the proto...

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Detalles Bibliográficos
Autores principales:	Maddur, Ashoka A., Voehler, Markus, Panizzi, Peter, Meiler, Jens, Bock, Paul E., Verhamme, Ingrid M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761706/ https://www.ncbi.nlm.nih.gov/pubmed/34915025 http://dx.doi.org/10.1016/j.jbc.2021.101493

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