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Cancer Stem Cells and the Tumor Microenvironment in Gastric Cancer

Gastric cancer (GC) remains one of the leading causes of cancer-related death worldwide. Cancer stem cells (CSCs) might be responsible for tumor initiation, relapse, metastasis and treatment resistance of GC. The tumor microenvironment (TME) comprises tumor cells, immune cells, stromal cells and oth...

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Detalles Bibliográficos
Autores principales: Yang, Ying, Meng, Wen-Jian, Wang, Zi-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761735/
https://www.ncbi.nlm.nih.gov/pubmed/35047411
http://dx.doi.org/10.3389/fonc.2021.803974
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author Yang, Ying
Meng, Wen-Jian
Wang, Zi-Qiang
author_facet Yang, Ying
Meng, Wen-Jian
Wang, Zi-Qiang
author_sort Yang, Ying
collection PubMed
description Gastric cancer (GC) remains one of the leading causes of cancer-related death worldwide. Cancer stem cells (CSCs) might be responsible for tumor initiation, relapse, metastasis and treatment resistance of GC. The tumor microenvironment (TME) comprises tumor cells, immune cells, stromal cells and other extracellular components, which plays a pivotal role in tumor progression and therapy resistance. The properties of CSCs are regulated by cells and extracellular matrix components of the TME in some unique manners. This review will summarize current literature regarding the effects of CSCs and TME on the progression and therapy resistance of GC, while emphasizing the potential for developing successful anti-tumor therapy based on targeting the TME and CSCs.
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spelling pubmed-87617352022-01-18 Cancer Stem Cells and the Tumor Microenvironment in Gastric Cancer Yang, Ying Meng, Wen-Jian Wang, Zi-Qiang Front Oncol Oncology Gastric cancer (GC) remains one of the leading causes of cancer-related death worldwide. Cancer stem cells (CSCs) might be responsible for tumor initiation, relapse, metastasis and treatment resistance of GC. The tumor microenvironment (TME) comprises tumor cells, immune cells, stromal cells and other extracellular components, which plays a pivotal role in tumor progression and therapy resistance. The properties of CSCs are regulated by cells and extracellular matrix components of the TME in some unique manners. This review will summarize current literature regarding the effects of CSCs and TME on the progression and therapy resistance of GC, while emphasizing the potential for developing successful anti-tumor therapy based on targeting the TME and CSCs. Frontiers Media S.A. 2022-01-03 /pmc/articles/PMC8761735/ /pubmed/35047411 http://dx.doi.org/10.3389/fonc.2021.803974 Text en Copyright © 2022 Yang, Meng and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yang, Ying
Meng, Wen-Jian
Wang, Zi-Qiang
Cancer Stem Cells and the Tumor Microenvironment in Gastric Cancer
title Cancer Stem Cells and the Tumor Microenvironment in Gastric Cancer
title_full Cancer Stem Cells and the Tumor Microenvironment in Gastric Cancer
title_fullStr Cancer Stem Cells and the Tumor Microenvironment in Gastric Cancer
title_full_unstemmed Cancer Stem Cells and the Tumor Microenvironment in Gastric Cancer
title_short Cancer Stem Cells and the Tumor Microenvironment in Gastric Cancer
title_sort cancer stem cells and the tumor microenvironment in gastric cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761735/
https://www.ncbi.nlm.nih.gov/pubmed/35047411
http://dx.doi.org/10.3389/fonc.2021.803974
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