The cGAS/STING Pathway: A Novel Target for Cancer Therapy

As a DNA receptor, cyclic GMP-AMP synthase (cGAS) plays a crucial role in the immune system by recognizing abnormal DNA in the cytoplasm and activating the stimulator of interferon genes (STING) signaling pathway. This signaling cascade reaction leads to an immune response produced by type I interfe...

Descripción completa

Detalles Bibliográficos
Autores principales: Gan, Yu, Li, Xiaoying, Han, Shuangze, Liang, Qi, Ma, Xiaoqian, Rong, Pengfei, Wang, Wei, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761794/
https://www.ncbi.nlm.nih.gov/pubmed/35046953
http://dx.doi.org/10.3389/fimmu.2021.795401
_version_ 1784633610659168256
author Gan, Yu
Li, Xiaoying
Han, Shuangze
Liang, Qi
Ma, Xiaoqian
Rong, Pengfei
Wang, Wei
Li, Wei
author_facet Gan, Yu
Li, Xiaoying
Han, Shuangze
Liang, Qi
Ma, Xiaoqian
Rong, Pengfei
Wang, Wei
Li, Wei
author_sort Gan, Yu
collection PubMed
description As a DNA receptor, cyclic GMP-AMP synthase (cGAS) plays a crucial role in the immune system by recognizing abnormal DNA in the cytoplasm and activating the stimulator of interferon genes (STING) signaling pathway. This signaling cascade reaction leads to an immune response produced by type I interferon and other immune mediators. Recent advances in research have enhanced our current understanding of the potential role of the cGAS/STING pathway in anticancer therapy; however, in some cases, chronic STING activation may promote tumorigenesis. The present review article discusses the biological mechanisms of the cGAS/STING pathway, its dichotomous role in tumors, and the latest advances with respect to STING agonists and antagonists.
format Online
Article
Text
id pubmed-8761794
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87617942022-01-18 The cGAS/STING Pathway: A Novel Target for Cancer Therapy Gan, Yu Li, Xiaoying Han, Shuangze Liang, Qi Ma, Xiaoqian Rong, Pengfei Wang, Wei Li, Wei Front Immunol Immunology As a DNA receptor, cyclic GMP-AMP synthase (cGAS) plays a crucial role in the immune system by recognizing abnormal DNA in the cytoplasm and activating the stimulator of interferon genes (STING) signaling pathway. This signaling cascade reaction leads to an immune response produced by type I interferon and other immune mediators. Recent advances in research have enhanced our current understanding of the potential role of the cGAS/STING pathway in anticancer therapy; however, in some cases, chronic STING activation may promote tumorigenesis. The present review article discusses the biological mechanisms of the cGAS/STING pathway, its dichotomous role in tumors, and the latest advances with respect to STING agonists and antagonists. Frontiers Media S.A. 2022-01-03 /pmc/articles/PMC8761794/ /pubmed/35046953 http://dx.doi.org/10.3389/fimmu.2021.795401 Text en Copyright © 2022 Gan, Li, Han, Liang, Ma, Rong, Wang and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Gan, Yu
Li, Xiaoying
Han, Shuangze
Liang, Qi
Ma, Xiaoqian
Rong, Pengfei
Wang, Wei
Li, Wei
The cGAS/STING Pathway: A Novel Target for Cancer Therapy
title The cGAS/STING Pathway: A Novel Target for Cancer Therapy
title_full The cGAS/STING Pathway: A Novel Target for Cancer Therapy
title_fullStr The cGAS/STING Pathway: A Novel Target for Cancer Therapy
title_full_unstemmed The cGAS/STING Pathway: A Novel Target for Cancer Therapy
title_short The cGAS/STING Pathway: A Novel Target for Cancer Therapy
title_sort cgas/sting pathway: a novel target for cancer therapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761794/
https://www.ncbi.nlm.nih.gov/pubmed/35046953
http://dx.doi.org/10.3389/fimmu.2021.795401
work_keys_str_mv AT ganyu thecgasstingpathwayanoveltargetforcancertherapy
AT lixiaoying thecgasstingpathwayanoveltargetforcancertherapy
AT hanshuangze thecgasstingpathwayanoveltargetforcancertherapy
AT liangqi thecgasstingpathwayanoveltargetforcancertherapy
AT maxiaoqian thecgasstingpathwayanoveltargetforcancertherapy
AT rongpengfei thecgasstingpathwayanoveltargetforcancertherapy
AT wangwei thecgasstingpathwayanoveltargetforcancertherapy
AT liwei thecgasstingpathwayanoveltargetforcancertherapy
AT ganyu cgasstingpathwayanoveltargetforcancertherapy
AT lixiaoying cgasstingpathwayanoveltargetforcancertherapy
AT hanshuangze cgasstingpathwayanoveltargetforcancertherapy
AT liangqi cgasstingpathwayanoveltargetforcancertherapy
AT maxiaoqian cgasstingpathwayanoveltargetforcancertherapy
AT rongpengfei cgasstingpathwayanoveltargetforcancertherapy
AT wangwei cgasstingpathwayanoveltargetforcancertherapy
AT liwei cgasstingpathwayanoveltargetforcancertherapy

Ejemplares similares