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Interleukin-8 and clinical symptoms can be prognostic indicators for advanced cancer patients with cachexia

OBJECTIVES: Prognostic prediction is a significant tool for selecting appropriate treatment in advanced cancer patients with cachexia, at a time when it is important to offer high-quality palliative care and improve quality of life until death. In this retrospective study, we investigated the progno...

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Autores principales: Murai, Miyo, Higashiguchi, Takashi, Futamura, Akihiko, Ohara, Hiroshi, Tsuzuki, Norimasa, Itani, Yoshinori, Kaneko, Takaaki, Chihara, Takeshi, Shimpo, Kan, Nakayama, Naomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fujita Medical Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761829/
https://www.ncbi.nlm.nih.gov/pubmed/35111532
http://dx.doi.org/10.20407/fmj.2018-022
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author Murai, Miyo
Higashiguchi, Takashi
Futamura, Akihiko
Ohara, Hiroshi
Tsuzuki, Norimasa
Itani, Yoshinori
Kaneko, Takaaki
Chihara, Takeshi
Shimpo, Kan
Nakayama, Naomi
author_facet Murai, Miyo
Higashiguchi, Takashi
Futamura, Akihiko
Ohara, Hiroshi
Tsuzuki, Norimasa
Itani, Yoshinori
Kaneko, Takaaki
Chihara, Takeshi
Shimpo, Kan
Nakayama, Naomi
author_sort Murai, Miyo
collection PubMed
description OBJECTIVES: Prognostic prediction is a significant tool for selecting appropriate treatment in advanced cancer patients with cachexia, at a time when it is important to offer high-quality palliative care and improve quality of life until death. In this retrospective study, we investigated the prognostic potential of serum cytokine level and various clinical symptoms by analyzing the pathological conditions and metabolic dynamics of cachexia in advanced cancer patients. METHODS: One hundred and fifty-three advanced cancer patients who underwent palliative care and died at the Department of Surgery and Palliative Medicine, Fujita Health University Nanakuri Memorial Hospital between 1 January 2004 and 30 June 2007 were eligible for the study. We simultaneously assessed their blood factors and clinical symptoms at admission. All patients were divided into two groups according to median survival time to analyze the risk factors for prognosis. RESULTS: Multivariate analysis revealed the following independent prognostic factors: interleukin (IL)-8 (odds ratio [OR]=4.17, 95% confidence interval [CI]=1.52–11.41, p=0.002), general fatigue (OR=1.22, 95%CI=1.03–1.45, p=0.019), anorexia (OR=1.19, 95%CI=1.04–1.37, p=0.008), dyspnea (OR=1.19, 95%CI=1.02–1.38, p=0.024), depression (OR=1.28, 95%CI=1.11–1.47, p<0.001), nausea (OR=1.25, 95%CI=1.05–1.48, p=0.007), dry mouth (OR=1.19, 95%CI=1.01–1.40, p=0.032), and overall assessment score (OR=1.05, 95%CI=1.02–1.09, p<0.001). Patients with low IL-8 (<1.347 pg/ml) and low overall assessment score (<26) had significantly better prognosis (both p<0.0001). CONCLUSIONS: High IL-8 level and clinical symptoms can be prognostic indicators for advanced cancer patients with cachexia.
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spelling pubmed-87618292022-02-01 Interleukin-8 and clinical symptoms can be prognostic indicators for advanced cancer patients with cachexia Murai, Miyo Higashiguchi, Takashi Futamura, Akihiko Ohara, Hiroshi Tsuzuki, Norimasa Itani, Yoshinori Kaneko, Takaaki Chihara, Takeshi Shimpo, Kan Nakayama, Naomi Fujita Med J Original Article OBJECTIVES: Prognostic prediction is a significant tool for selecting appropriate treatment in advanced cancer patients with cachexia, at a time when it is important to offer high-quality palliative care and improve quality of life until death. In this retrospective study, we investigated the prognostic potential of serum cytokine level and various clinical symptoms by analyzing the pathological conditions and metabolic dynamics of cachexia in advanced cancer patients. METHODS: One hundred and fifty-three advanced cancer patients who underwent palliative care and died at the Department of Surgery and Palliative Medicine, Fujita Health University Nanakuri Memorial Hospital between 1 January 2004 and 30 June 2007 were eligible for the study. We simultaneously assessed their blood factors and clinical symptoms at admission. All patients were divided into two groups according to median survival time to analyze the risk factors for prognosis. RESULTS: Multivariate analysis revealed the following independent prognostic factors: interleukin (IL)-8 (odds ratio [OR]=4.17, 95% confidence interval [CI]=1.52–11.41, p=0.002), general fatigue (OR=1.22, 95%CI=1.03–1.45, p=0.019), anorexia (OR=1.19, 95%CI=1.04–1.37, p=0.008), dyspnea (OR=1.19, 95%CI=1.02–1.38, p=0.024), depression (OR=1.28, 95%CI=1.11–1.47, p<0.001), nausea (OR=1.25, 95%CI=1.05–1.48, p=0.007), dry mouth (OR=1.19, 95%CI=1.01–1.40, p=0.032), and overall assessment score (OR=1.05, 95%CI=1.02–1.09, p<0.001). Patients with low IL-8 (<1.347 pg/ml) and low overall assessment score (<26) had significantly better prognosis (both p<0.0001). CONCLUSIONS: High IL-8 level and clinical symptoms can be prognostic indicators for advanced cancer patients with cachexia. Fujita Medical Society 2020 2020-03-25 /pmc/articles/PMC8761829/ /pubmed/35111532 http://dx.doi.org/10.20407/fmj.2018-022 Text en https://creativecommons.org/licenses/by/4.0/This is an Open access article distributed under the Terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Murai, Miyo
Higashiguchi, Takashi
Futamura, Akihiko
Ohara, Hiroshi
Tsuzuki, Norimasa
Itani, Yoshinori
Kaneko, Takaaki
Chihara, Takeshi
Shimpo, Kan
Nakayama, Naomi
Interleukin-8 and clinical symptoms can be prognostic indicators for advanced cancer patients with cachexia
title Interleukin-8 and clinical symptoms can be prognostic indicators for advanced cancer patients with cachexia
title_full Interleukin-8 and clinical symptoms can be prognostic indicators for advanced cancer patients with cachexia
title_fullStr Interleukin-8 and clinical symptoms can be prognostic indicators for advanced cancer patients with cachexia
title_full_unstemmed Interleukin-8 and clinical symptoms can be prognostic indicators for advanced cancer patients with cachexia
title_short Interleukin-8 and clinical symptoms can be prognostic indicators for advanced cancer patients with cachexia
title_sort interleukin-8 and clinical symptoms can be prognostic indicators for advanced cancer patients with cachexia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761829/
https://www.ncbi.nlm.nih.gov/pubmed/35111532
http://dx.doi.org/10.20407/fmj.2018-022
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