Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation

Accumulation of somatic hypermutation (SHM) is the primary mechanism to enhance the binding affinity of antibodies to antigens in vivo. However, the structural basis of the effects of many SHMs remains elusive. Here, we integrated atomistic molecular dynamics (MD) simulation and data mining to build...

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Detalles Bibliográficos
Autores principales: Sheng, Zizhang, Bimela, Jude S., Katsamba, Phinikoula S., Patel, Saurabh D., Guo, Yicheng, Zhao, Haiqing, Guo, Youzhong, Kwong, Peter D., Shapiro, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761896/
https://www.ncbi.nlm.nih.gov/pubmed/35046963
http://dx.doi.org/10.3389/fimmu.2021.811632

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