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Acute Kidney Injury Biomarkers and Hydration Outcomes at the Boston Marathon

The purpose of our field study was to investigate the effects of running the Boston Marathon on acute kidney injury (AKI) biomarkers. We hypothesized that biomarker values would be elevated immediately post-marathon but would resolve in the 24-h post-marathon. Secondarily, we sought to identify sex...

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Autores principales: Atkins, Whitley C., Butts, Cory L., Kelly, Melani R., Troyanos, Chris, Laursen, R. Mark, Duckett, Andrew, Emerson, Dawn M., Rosa-Caldwell, Megan E., McDermott, Brendon P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761943/
https://www.ncbi.nlm.nih.gov/pubmed/35046841
http://dx.doi.org/10.3389/fphys.2021.813554
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author Atkins, Whitley C.
Butts, Cory L.
Kelly, Melani R.
Troyanos, Chris
Laursen, R. Mark
Duckett, Andrew
Emerson, Dawn M.
Rosa-Caldwell, Megan E.
McDermott, Brendon P.
author_facet Atkins, Whitley C.
Butts, Cory L.
Kelly, Melani R.
Troyanos, Chris
Laursen, R. Mark
Duckett, Andrew
Emerson, Dawn M.
Rosa-Caldwell, Megan E.
McDermott, Brendon P.
author_sort Atkins, Whitley C.
collection PubMed
description The purpose of our field study was to investigate the effects of running the Boston Marathon on acute kidney injury (AKI) biomarkers. We hypothesized that biomarker values would be elevated immediately post-marathon but would resolve in the 24-h post-marathon. Secondarily, we sought to identify sex differences related to renal stress. Participants were 65 runners who completed the Boston Marathon (46 ± 9 years, 65.4 ± 10.8 kg). Urine samples were collected at three different time points (pre-marathon, post-marathon, and 24-h post-marathon). Blood samples were collected post-marathon and 24-h post-marathon. Urine specific gravity (USG) and AKI biomarkers were evaluated. Pre-marathon USG (1.012 ± 0.007) was significantly less than post-marathon (1.018 ± 0.008) and 24-h post-marathon (1.020 ± 0.009; P < 0.001). Male USG (1.024 ± 0.009) was significantly greater 24-h post-marathon than females (1.017 ± 0.008; P = 0.019). Urinary neutrophil gelatinase-associated lipocalin values were significantly greater over time (P < 0.001), and there was a main effect of sex with female urinary creatinine ((U)Cr) greater than males at all three time points (P = 0.040). Post-marathon(U)Cr (366.24 ± 295.16 mg/dl) was significantly greater than pre-marathon (206.65 ± 145.28.56 mg/dl; p < 0.001) and 24-h post-marathon was significantly lower than other time-points (93.90 ± 125.07 mg/dl; P < 0.001). Female(U)Cr values were significantly greater than males 24-h post-marathon (P < 0.001). There was no difference in serum cystatin C ((S)Cys) values post- or 24-h post-marathon (P = 0.178). Serum creatinine ((S)Cr) significantly decreased between post-marathon and 24-h post-marathon, (P < 0.001). We can infer that the characteristics unique to the Boston Marathon may have attributed to prolonged elevations in AKI biomarkers. Sex differences were observed during the Boston Marathon warranting further investigation.
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spelling pubmed-87619432022-01-18 Acute Kidney Injury Biomarkers and Hydration Outcomes at the Boston Marathon Atkins, Whitley C. Butts, Cory L. Kelly, Melani R. Troyanos, Chris Laursen, R. Mark Duckett, Andrew Emerson, Dawn M. Rosa-Caldwell, Megan E. McDermott, Brendon P. Front Physiol Physiology The purpose of our field study was to investigate the effects of running the Boston Marathon on acute kidney injury (AKI) biomarkers. We hypothesized that biomarker values would be elevated immediately post-marathon but would resolve in the 24-h post-marathon. Secondarily, we sought to identify sex differences related to renal stress. Participants were 65 runners who completed the Boston Marathon (46 ± 9 years, 65.4 ± 10.8 kg). Urine samples were collected at three different time points (pre-marathon, post-marathon, and 24-h post-marathon). Blood samples were collected post-marathon and 24-h post-marathon. Urine specific gravity (USG) and AKI biomarkers were evaluated. Pre-marathon USG (1.012 ± 0.007) was significantly less than post-marathon (1.018 ± 0.008) and 24-h post-marathon (1.020 ± 0.009; P < 0.001). Male USG (1.024 ± 0.009) was significantly greater 24-h post-marathon than females (1.017 ± 0.008; P = 0.019). Urinary neutrophil gelatinase-associated lipocalin values were significantly greater over time (P < 0.001), and there was a main effect of sex with female urinary creatinine ((U)Cr) greater than males at all three time points (P = 0.040). Post-marathon(U)Cr (366.24 ± 295.16 mg/dl) was significantly greater than pre-marathon (206.65 ± 145.28.56 mg/dl; p < 0.001) and 24-h post-marathon was significantly lower than other time-points (93.90 ± 125.07 mg/dl; P < 0.001). Female(U)Cr values were significantly greater than males 24-h post-marathon (P < 0.001). There was no difference in serum cystatin C ((S)Cys) values post- or 24-h post-marathon (P = 0.178). Serum creatinine ((S)Cr) significantly decreased between post-marathon and 24-h post-marathon, (P < 0.001). We can infer that the characteristics unique to the Boston Marathon may have attributed to prolonged elevations in AKI biomarkers. Sex differences were observed during the Boston Marathon warranting further investigation. Frontiers Media S.A. 2022-01-03 /pmc/articles/PMC8761943/ /pubmed/35046841 http://dx.doi.org/10.3389/fphys.2021.813554 Text en Copyright © 2022 Atkins, Butts, Kelly, Troyanos, Laursen, Duckett, Emerson, Rosa-Caldwell and McDermott. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Atkins, Whitley C.
Butts, Cory L.
Kelly, Melani R.
Troyanos, Chris
Laursen, R. Mark
Duckett, Andrew
Emerson, Dawn M.
Rosa-Caldwell, Megan E.
McDermott, Brendon P.
Acute Kidney Injury Biomarkers and Hydration Outcomes at the Boston Marathon
title Acute Kidney Injury Biomarkers and Hydration Outcomes at the Boston Marathon
title_full Acute Kidney Injury Biomarkers and Hydration Outcomes at the Boston Marathon
title_fullStr Acute Kidney Injury Biomarkers and Hydration Outcomes at the Boston Marathon
title_full_unstemmed Acute Kidney Injury Biomarkers and Hydration Outcomes at the Boston Marathon
title_short Acute Kidney Injury Biomarkers and Hydration Outcomes at the Boston Marathon
title_sort acute kidney injury biomarkers and hydration outcomes at the boston marathon
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761943/
https://www.ncbi.nlm.nih.gov/pubmed/35046841
http://dx.doi.org/10.3389/fphys.2021.813554
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