Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide

Reduction of the risk of asthma attacks is a major goal of current asthma management. We propose to derive a risk scale predicting asthma attacks based on the blood eosinophil count and exhaled nitric oxide (FeNO). Biomarker-stratified trial-level attack rates were extracted and pooled from the cont...

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Autores principales: Couillard, Simon, Laugerud, Annette, Jabeen, Maisha, Ramakrishnan, Sanjay, Melhorn, James, Hinks, Timothy, Pavord, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762000/
https://www.ncbi.nlm.nih.gov/pubmed/34362839
http://dx.doi.org/10.1136/thoraxjnl-2021-217325
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author Couillard, Simon
Laugerud, Annette
Jabeen, Maisha
Ramakrishnan, Sanjay
Melhorn, James
Hinks, Timothy
Pavord, Ian
author_facet Couillard, Simon
Laugerud, Annette
Jabeen, Maisha
Ramakrishnan, Sanjay
Melhorn, James
Hinks, Timothy
Pavord, Ian
author_sort Couillard, Simon
collection PubMed
description Reduction of the risk of asthma attacks is a major goal of current asthma management. We propose to derive a risk scale predicting asthma attacks based on the blood eosinophil count and exhaled nitric oxide (FeNO). Biomarker-stratified trial-level attack rates were extracted and pooled from the control arms of the Novel START, CAPTAIN, QUEST, Benralizumab Phase 2b, PATHWAY, STRATOS 1–2 and DREAM trials (n=3051). These were used to derive rate ratios and the predicted asthma attack rate for different patient groups. The resultant prototype risk scale shows potential to predict asthma attacks, which may be prevented by anti-inflammatory treatment.
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spelling pubmed-87620002022-01-26 Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide Couillard, Simon Laugerud, Annette Jabeen, Maisha Ramakrishnan, Sanjay Melhorn, James Hinks, Timothy Pavord, Ian Thorax Brief Communication Reduction of the risk of asthma attacks is a major goal of current asthma management. We propose to derive a risk scale predicting asthma attacks based on the blood eosinophil count and exhaled nitric oxide (FeNO). Biomarker-stratified trial-level attack rates were extracted and pooled from the control arms of the Novel START, CAPTAIN, QUEST, Benralizumab Phase 2b, PATHWAY, STRATOS 1–2 and DREAM trials (n=3051). These were used to derive rate ratios and the predicted asthma attack rate for different patient groups. The resultant prototype risk scale shows potential to predict asthma attacks, which may be prevented by anti-inflammatory treatment. BMJ Publishing Group 2022-02 2021-08-06 /pmc/articles/PMC8762000/ /pubmed/34362839 http://dx.doi.org/10.1136/thoraxjnl-2021-217325 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Couillard, Simon
Laugerud, Annette
Jabeen, Maisha
Ramakrishnan, Sanjay
Melhorn, James
Hinks, Timothy
Pavord, Ian
Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide
title Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide
title_full Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide
title_fullStr Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide
title_full_unstemmed Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide
title_short Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide
title_sort derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762000/
https://www.ncbi.nlm.nih.gov/pubmed/34362839
http://dx.doi.org/10.1136/thoraxjnl-2021-217325
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