Targeting the IL-6–Yap–Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis

OBJECTIVE: We aimed to understand the role of the transcriptional co-factor Yes-associated protein (Yap) in the molecular pathway underpinning the pathogenic transformation of synovial fibroblasts (SF) in rheumatoid arthritis (RA) to become invasive and cause joint destruction. METHODS: Synovium fro...

Descripción completa

Detalles Bibliográficos
Autores principales: Symons, Rebecca A, Colella, Fabio, Collins, Fraser L, Rafipay, Alexandra J, Kania, Karolina, McClure, Jessica J, White, Nathan, Cunningham, Iain, Ashraf, Sadaf, Hay, Elizabeth, Mackenzie, Kevin S, Howard, Kenneth A, Riemen, Anna H K, Manzo, Antonio, Clark, Susan M, Roelofs, Anke J, De Bari, Cosimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Inflammatory Arthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762018/
https://www.ncbi.nlm.nih.gov/pubmed/34844926
http://dx.doi.org/10.1136/annrheumdis-2021-220875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762018/
https://www.ncbi.nlm.nih.gov/pubmed/34844926
http://dx.doi.org/10.1136/annrheumdis-2021-220875

Ejemplares similares