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Splicing machinery is impaired in rheumatoid arthritis, associated with disease activity and modulated by anti-TNF therapy

OBJECTIVES: To characterise splicing machinery (SM) alterations in leucocytes of patients with rheumatoid arthritis (RA), and to assess its influence on their clinical profile and therapeutic response. METHODS: Leucocyte subtypes from 129 patients with RA and 29 healthy donors (HD) were purified, an...

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Detalles Bibliográficos
Autores principales:	Ibáñez-Costa, Alejandro, Perez-Sanchez, Carlos, Patiño-Trives, Alejandra María, Luque-Tevar, Maria, Font, Pilar, Arias de la Rosa, Ivan, Roman-Rodriguez, Cristobal, Abalos-Aguilera, Mª Carmen, Conde, Carmen, Gonzalez, Antonio, Pedraza-Arevalo, Sergio, del Rio-Moreno, Mercedes, Blazquez-Encinas, Ricardo, Segui, Pedro, Calvo, Jerusalem, Ortega Castro, Rafaela, Escudero-Contreras, Alejandro, Barbarroja, Nuria, Aguirre, Mª Angeles, Castaño, Justo P, Luque, Raul M, Collantes-Estevez, Eduardo, Lopez-Pedrera, Chary
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Rheumatoid Arthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762032/ https://www.ncbi.nlm.nih.gov/pubmed/34625402 http://dx.doi.org/10.1136/annrheumdis-2021-220308

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