Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions

OBJECTIVE: Cellular senescence limits tumourigenesis by blocking the proliferation of premalignant cells. Additionally, however, senescent cells can exert paracrine effects influencing tumour growth. Senescent cells are present in premalignant pancreatic intraepithelial neoplasia (PanIN) lesions, ye...

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Detalles Bibliográficos
Autores principales: Kolodkin-Gal, Dror, Roitman, Lior, Ovadya, Yossi, Azazmeh, Narmen, Assouline, Benjamin, Schlesinger, Yehuda, Kalifa, Rachel, Horwitz, Shaul, Khalatnik, Yonatan, Hochner-Ger, Anna, Imam, Ashraf, Demma, Jonathan Abraham, Winter, Eitan, Benyamini, Hadar, Elgavish, Sharona, Khatib, Areej AS, Meir, Karen, Atlan, Karine, Pikarsky, Eli, Parnas, Oren, Dor, Yuval, Zamir, Gideon, Ben-Porath, Ittai, Krizhanovsky, Valery
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Pancreas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762039/
https://www.ncbi.nlm.nih.gov/pubmed/33649045
http://dx.doi.org/10.1136/gutjnl-2020-321112

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