An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins

Recognition of human autophagy-related 8 (hATG8) proteins by autophagy receptors represents a critical step within this cellular quality control system. Autophagy impairment is known to be a pathogenic mechanism in the motor neuron disorder amyotrophic lateral sclerosis (ALS). Overlapping but specif...

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Detalles Bibliográficos
Autores principales: Brennan, Andrew, Layfield, Robert, Long, Jed, Williams, Huw E.L., Oldham, Neil J., Scott, Daniel, Searle, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762078/
https://www.ncbi.nlm.nih.gov/pubmed/34929165
http://dx.doi.org/10.1016/j.jbc.2021.101514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762078/
https://www.ncbi.nlm.nih.gov/pubmed/34929165
http://dx.doi.org/10.1016/j.jbc.2021.101514

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