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An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins

Recognition of human autophagy-related 8 (hATG8) proteins by autophagy receptors represents a critical step within this cellular quality control system. Autophagy impairment is known to be a pathogenic mechanism in the motor neuron disorder amyotrophic lateral sclerosis (ALS). Overlapping but specif...

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Detalles Bibliográficos
Autores principales:	Brennan, Andrew, Layfield, Robert, Long, Jed, Williams, Huw E.L., Oldham, Neil J., Scott, Daniel, Searle, Mark S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762078/ https://www.ncbi.nlm.nih.gov/pubmed/34929165 http://dx.doi.org/10.1016/j.jbc.2021.101514

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