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Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors

BACKGROUND: Adoptive T-cell transfer has become an attractive therapeutic approach for hematological malignancies but shows poor activity against large and heterogeneous solid tumors. Interleukin-12 (IL-12) exhibits potent antitumor efficacy against solid tumors, but its clinical application has bee...

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Detalles Bibliográficos
Autores principales:	Hu, Jiemiao, Yang, Qing, Zhang, Wendong, Du, Hongwei, Chen, Yuhui, Zhao, Qingnan, Dao, Long, Xia, Xueqing, Natalie Wall, Fowlkes, Zhang, Zhongting, Mahadeo, Kris, Gorlick, Richard, Kopetz, S, Dotti, Gianpietro, Li, Shulin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762133/ https://www.ncbi.nlm.nih.gov/pubmed/35027427 http://dx.doi.org/10.1136/jitc-2021-003633

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