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Autophagy of the Nucleus in Health and Disease

Nucleophagy is an organelle-selective subtype of autophagy that targets nuclear material for degradation. The macroautophagic delivery of micronuclei to the vacuole, together with the nucleus-vacuole junction-dependent microautophagic degradation of nuclear material, were first observed in yeast. Nu...

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Autores principales: Konstantinidis, Georgios, Tavernarakis, Nektarios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762222/
https://www.ncbi.nlm.nih.gov/pubmed/35047516
http://dx.doi.org/10.3389/fcell.2021.814955
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author Konstantinidis, Georgios
Tavernarakis, Nektarios
author_facet Konstantinidis, Georgios
Tavernarakis, Nektarios
author_sort Konstantinidis, Georgios
collection PubMed
description Nucleophagy is an organelle-selective subtype of autophagy that targets nuclear material for degradation. The macroautophagic delivery of micronuclei to the vacuole, together with the nucleus-vacuole junction-dependent microautophagic degradation of nuclear material, were first observed in yeast. Nuclear pore complexes and ribosomal DNA are typically excluded during conventional macronucleophagy and micronucleophagy, indicating that degradation of nuclear cargo is tightly regulated. In mammals, similarly to other autophagy subtypes, nucleophagy is crucial for cellular differentiation and development, in addition to enabling cells to respond to various nuclear insults and cell cycle perturbations. A common denominator of all nucleophagic processes characterized in diverse organisms is the dependence on the core autophagic machinery. Here, we survey recent studies investigating the autophagic processing of nuclear components. We discuss nucleophagic events in the context of pathology, such as neurodegeneration, cancer, DNA damage, and ageing.
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spelling pubmed-87622222022-01-18 Autophagy of the Nucleus in Health and Disease Konstantinidis, Georgios Tavernarakis, Nektarios Front Cell Dev Biol Cell and Developmental Biology Nucleophagy is an organelle-selective subtype of autophagy that targets nuclear material for degradation. The macroautophagic delivery of micronuclei to the vacuole, together with the nucleus-vacuole junction-dependent microautophagic degradation of nuclear material, were first observed in yeast. Nuclear pore complexes and ribosomal DNA are typically excluded during conventional macronucleophagy and micronucleophagy, indicating that degradation of nuclear cargo is tightly regulated. In mammals, similarly to other autophagy subtypes, nucleophagy is crucial for cellular differentiation and development, in addition to enabling cells to respond to various nuclear insults and cell cycle perturbations. A common denominator of all nucleophagic processes characterized in diverse organisms is the dependence on the core autophagic machinery. Here, we survey recent studies investigating the autophagic processing of nuclear components. We discuss nucleophagic events in the context of pathology, such as neurodegeneration, cancer, DNA damage, and ageing. Frontiers Media S.A. 2022-01-03 /pmc/articles/PMC8762222/ /pubmed/35047516 http://dx.doi.org/10.3389/fcell.2021.814955 Text en Copyright © 2022 Konstantinidis and Tavernarakis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Konstantinidis, Georgios
Tavernarakis, Nektarios
Autophagy of the Nucleus in Health and Disease
title Autophagy of the Nucleus in Health and Disease
title_full Autophagy of the Nucleus in Health and Disease
title_fullStr Autophagy of the Nucleus in Health and Disease
title_full_unstemmed Autophagy of the Nucleus in Health and Disease
title_short Autophagy of the Nucleus in Health and Disease
title_sort autophagy of the nucleus in health and disease
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762222/
https://www.ncbi.nlm.nih.gov/pubmed/35047516
http://dx.doi.org/10.3389/fcell.2021.814955
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