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A Review on the Role of miR-1246 in the Pathoetiology of Different Cancers
miR-1246 is a microRNA firstly recognized through application of a high throughput sequencing technique in human embryonic stem cells. Subsequent studies have shown the role of this microRNA in the carcinogenesis. miR-1246 has been found to exert oncogenic roles in colorectal, breast, renal, oral, l...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762223/ https://www.ncbi.nlm.nih.gov/pubmed/35047553 http://dx.doi.org/10.3389/fmolb.2021.771835 |
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author | Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Taheri, Mohammad Samadian, Mohammad |
author_facet | Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Taheri, Mohammad Samadian, Mohammad |
author_sort | Ghafouri-Fard, Soudeh |
collection | PubMed |
description | miR-1246 is a microRNA firstly recognized through application of a high throughput sequencing technique in human embryonic stem cells. Subsequent studies have shown the role of this microRNA in the carcinogenesis. miR-1246 has been found to exert oncogenic roles in colorectal, breast, renal, oral, laryngeal, pancreatic and ovarian cancers as well as melanoma and glioma. In lung, cervical and liver cancers, studies have reported contradictory results regarding the role of miR-1246. miR-1246 has been reported to regulate activity of RAF/MEK/ERK, GSK3β, Wnt/β-catenin, JAK/STAT, PI3K/AKT, THBS2/MMP and NOTCH2 pathways. In addition to affecting cell cycle progression and proliferation, miR-1246 can influence stemness and resistance of cancer cells to therapeutics. In the current review, we describe the summary of in vitro and in vivo studies about the influence of miR-1246 in carcinogenesis in addition to studies that measured expression levels of miR-1246 in clinical samples. |
format | Online Article Text |
id | pubmed-8762223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87622232022-01-18 A Review on the Role of miR-1246 in the Pathoetiology of Different Cancers Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Taheri, Mohammad Samadian, Mohammad Front Mol Biosci Molecular Biosciences miR-1246 is a microRNA firstly recognized through application of a high throughput sequencing technique in human embryonic stem cells. Subsequent studies have shown the role of this microRNA in the carcinogenesis. miR-1246 has been found to exert oncogenic roles in colorectal, breast, renal, oral, laryngeal, pancreatic and ovarian cancers as well as melanoma and glioma. In lung, cervical and liver cancers, studies have reported contradictory results regarding the role of miR-1246. miR-1246 has been reported to regulate activity of RAF/MEK/ERK, GSK3β, Wnt/β-catenin, JAK/STAT, PI3K/AKT, THBS2/MMP and NOTCH2 pathways. In addition to affecting cell cycle progression and proliferation, miR-1246 can influence stemness and resistance of cancer cells to therapeutics. In the current review, we describe the summary of in vitro and in vivo studies about the influence of miR-1246 in carcinogenesis in addition to studies that measured expression levels of miR-1246 in clinical samples. Frontiers Media S.A. 2022-01-03 /pmc/articles/PMC8762223/ /pubmed/35047553 http://dx.doi.org/10.3389/fmolb.2021.771835 Text en Copyright © 2022 Ghafouri-Fard, Khoshbakht, Hussen, Taheri and Samadian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Taheri, Mohammad Samadian, Mohammad A Review on the Role of miR-1246 in the Pathoetiology of Different Cancers |
title | A Review on the Role of miR-1246 in the Pathoetiology of Different Cancers |
title_full | A Review on the Role of miR-1246 in the Pathoetiology of Different Cancers |
title_fullStr | A Review on the Role of miR-1246 in the Pathoetiology of Different Cancers |
title_full_unstemmed | A Review on the Role of miR-1246 in the Pathoetiology of Different Cancers |
title_short | A Review on the Role of miR-1246 in the Pathoetiology of Different Cancers |
title_sort | review on the role of mir-1246 in the pathoetiology of different cancers |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762223/ https://www.ncbi.nlm.nih.gov/pubmed/35047553 http://dx.doi.org/10.3389/fmolb.2021.771835 |
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