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BCNet: A Novel Network for Blood Cell Classification
Aims: Most blood diseases, such as chronic anemia, leukemia (commonly known as blood cancer), and hematopoietic dysfunction, are caused by environmental pollution, substandard decoration materials, radiation exposure, and long-term use certain drugs. Thus, it is imperative to classify the blood cell...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762289/ https://www.ncbi.nlm.nih.gov/pubmed/35047515 http://dx.doi.org/10.3389/fcell.2021.813996 |
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author | Zhu, Ziquan Lu, Siyuan Wang, Shui-Hua Górriz, Juan Manuel Zhang, Yu-Dong |
author_facet | Zhu, Ziquan Lu, Siyuan Wang, Shui-Hua Górriz, Juan Manuel Zhang, Yu-Dong |
author_sort | Zhu, Ziquan |
collection | PubMed |
description | Aims: Most blood diseases, such as chronic anemia, leukemia (commonly known as blood cancer), and hematopoietic dysfunction, are caused by environmental pollution, substandard decoration materials, radiation exposure, and long-term use certain drugs. Thus, it is imperative to classify the blood cell images. Most cell classification is based on the manual feature, machine learning classifier or the deep convolution network neural model. However, manual feature extraction is a very tedious process, and the results are usually unsatisfactory. On the other hand, the deep convolution neural network is usually composed of massive layers, and each layer has many parameters. Therefore, each deep convolution neural network needs a lot of time to get the results. Another problem is that medical data sets are relatively small, which may lead to overfitting problems. Methods: To address these problems, we propose seven models for the automatic classification of blood cells: BCARENet, BCR5RENet, BCMV2RENet, BCRRNet, BCRENet, BCRSNet, and BCNet. The BCNet model is the best model among the seven proposed models. The backbone model in our method is selected as the ResNet-18, which is pre-trained on the ImageNet set. To improve the performance of the proposed model, we replace the last four layers of the trained transferred ResNet-18 model with the three randomized neural networks (RNNs), which are RVFL, ELM, and SNN. The final outputs of our BCNet are generated by the ensemble of the predictions from the three randomized neural networks by the majority voting. We use four multi-classification indexes for the evaluation of our model. Results: The accuracy, average precision, average F1-score, and average recall are 96.78, 97.07, 96.78, and 96.77%, respectively. Conclusion: We offer the comparison of our model with state-of-the-art methods. The results of the proposed BCNet model are much better than other state-of-the-art methods. |
format | Online Article Text |
id | pubmed-8762289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87622892022-01-18 BCNet: A Novel Network for Blood Cell Classification Zhu, Ziquan Lu, Siyuan Wang, Shui-Hua Górriz, Juan Manuel Zhang, Yu-Dong Front Cell Dev Biol Cell and Developmental Biology Aims: Most blood diseases, such as chronic anemia, leukemia (commonly known as blood cancer), and hematopoietic dysfunction, are caused by environmental pollution, substandard decoration materials, radiation exposure, and long-term use certain drugs. Thus, it is imperative to classify the blood cell images. Most cell classification is based on the manual feature, machine learning classifier or the deep convolution network neural model. However, manual feature extraction is a very tedious process, and the results are usually unsatisfactory. On the other hand, the deep convolution neural network is usually composed of massive layers, and each layer has many parameters. Therefore, each deep convolution neural network needs a lot of time to get the results. Another problem is that medical data sets are relatively small, which may lead to overfitting problems. Methods: To address these problems, we propose seven models for the automatic classification of blood cells: BCARENet, BCR5RENet, BCMV2RENet, BCRRNet, BCRENet, BCRSNet, and BCNet. The BCNet model is the best model among the seven proposed models. The backbone model in our method is selected as the ResNet-18, which is pre-trained on the ImageNet set. To improve the performance of the proposed model, we replace the last four layers of the trained transferred ResNet-18 model with the three randomized neural networks (RNNs), which are RVFL, ELM, and SNN. The final outputs of our BCNet are generated by the ensemble of the predictions from the three randomized neural networks by the majority voting. We use four multi-classification indexes for the evaluation of our model. Results: The accuracy, average precision, average F1-score, and average recall are 96.78, 97.07, 96.78, and 96.77%, respectively. Conclusion: We offer the comparison of our model with state-of-the-art methods. The results of the proposed BCNet model are much better than other state-of-the-art methods. Frontiers Media S.A. 2022-01-03 /pmc/articles/PMC8762289/ /pubmed/35047515 http://dx.doi.org/10.3389/fcell.2021.813996 Text en Copyright © 2022 Zhu, Lu, Wang, Górriz and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zhu, Ziquan Lu, Siyuan Wang, Shui-Hua Górriz, Juan Manuel Zhang, Yu-Dong BCNet: A Novel Network for Blood Cell Classification |
title | BCNet: A Novel Network for Blood Cell Classification |
title_full | BCNet: A Novel Network for Blood Cell Classification |
title_fullStr | BCNet: A Novel Network for Blood Cell Classification |
title_full_unstemmed | BCNet: A Novel Network for Blood Cell Classification |
title_short | BCNet: A Novel Network for Blood Cell Classification |
title_sort | bcnet: a novel network for blood cell classification |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762289/ https://www.ncbi.nlm.nih.gov/pubmed/35047515 http://dx.doi.org/10.3389/fcell.2021.813996 |
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