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Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression
We examined amygdala subregion volumes in patients with a first episode of major depression (MD) and in healthy subjects. Covariate-adjusted linear regression was performed to compare the MD and healthy groups, and adjustments for age, gender, and total estimated intracranial volume showed no differ...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762364/ https://www.ncbi.nlm.nih.gov/pubmed/35046783 http://dx.doi.org/10.3389/fnhum.2021.780884 |
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author | Tesen, Hirofumi Watanabe, Keita Okamoto, Naomichi Ikenouchi, Atsuko Igata, Ryohei Konishi, Yuki Kakeda, Shingo Yoshimura, Reiji |
author_facet | Tesen, Hirofumi Watanabe, Keita Okamoto, Naomichi Ikenouchi, Atsuko Igata, Ryohei Konishi, Yuki Kakeda, Shingo Yoshimura, Reiji |
author_sort | Tesen, Hirofumi |
collection | PubMed |
description | We examined amygdala subregion volumes in patients with a first episode of major depression (MD) and in healthy subjects. Covariate-adjusted linear regression was performed to compare the MD and healthy groups, and adjustments for age, gender, and total estimated intracranial volume showed no differences in amygdala subregion volumes between the healthy and MD groups. Within the MD group, we examined the association between amygdala subregion volume and the 17-item Hamilton Rating Scale for Depression (HAMD) score and the HAMD subscale score, and found no association in the left amygdala. In the right amygdala, however, there was an inverse linear association between the HAMD total and the HAMD core and lateral nucleus and anterior-amygdaloid-regions. Furthermore, an inverse linear association was seen between the HAMD psychic and the lateral nucleus, anterior-amygdaloid-regions, transition, and whole amygdala. The findings of this study suggest that the severity of MD and some symptoms of MD are associated with right amygdala volume. There have been few reports on the relationship between MD and amygdala subregional volume, and further research is needed to accumulate more data for further validation. |
format | Online Article Text |
id | pubmed-8762364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87623642022-01-18 Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression Tesen, Hirofumi Watanabe, Keita Okamoto, Naomichi Ikenouchi, Atsuko Igata, Ryohei Konishi, Yuki Kakeda, Shingo Yoshimura, Reiji Front Hum Neurosci Neuroscience We examined amygdala subregion volumes in patients with a first episode of major depression (MD) and in healthy subjects. Covariate-adjusted linear regression was performed to compare the MD and healthy groups, and adjustments for age, gender, and total estimated intracranial volume showed no differences in amygdala subregion volumes between the healthy and MD groups. Within the MD group, we examined the association between amygdala subregion volume and the 17-item Hamilton Rating Scale for Depression (HAMD) score and the HAMD subscale score, and found no association in the left amygdala. In the right amygdala, however, there was an inverse linear association between the HAMD total and the HAMD core and lateral nucleus and anterior-amygdaloid-regions. Furthermore, an inverse linear association was seen between the HAMD psychic and the lateral nucleus, anterior-amygdaloid-regions, transition, and whole amygdala. The findings of this study suggest that the severity of MD and some symptoms of MD are associated with right amygdala volume. There have been few reports on the relationship between MD and amygdala subregional volume, and further research is needed to accumulate more data for further validation. Frontiers Media S.A. 2022-01-03 /pmc/articles/PMC8762364/ /pubmed/35046783 http://dx.doi.org/10.3389/fnhum.2021.780884 Text en Copyright © 2022 Tesen, Watanabe, Okamoto, Ikenouchi, Igata, Konishi, Kakeda and Yoshimura. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Tesen, Hirofumi Watanabe, Keita Okamoto, Naomichi Ikenouchi, Atsuko Igata, Ryohei Konishi, Yuki Kakeda, Shingo Yoshimura, Reiji Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression |
title | Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression |
title_full | Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression |
title_fullStr | Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression |
title_full_unstemmed | Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression |
title_short | Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression |
title_sort | volume of amygdala subregions and clinical manifestations in patients with first-episode, drug-naïve major depression |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762364/ https://www.ncbi.nlm.nih.gov/pubmed/35046783 http://dx.doi.org/10.3389/fnhum.2021.780884 |
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