Cargando…

Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression

We examined amygdala subregion volumes in patients with a first episode of major depression (MD) and in healthy subjects. Covariate-adjusted linear regression was performed to compare the MD and healthy groups, and adjustments for age, gender, and total estimated intracranial volume showed no differ...

Descripción completa

Detalles Bibliográficos
Autores principales: Tesen, Hirofumi, Watanabe, Keita, Okamoto, Naomichi, Ikenouchi, Atsuko, Igata, Ryohei, Konishi, Yuki, Kakeda, Shingo, Yoshimura, Reiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762364/
https://www.ncbi.nlm.nih.gov/pubmed/35046783
http://dx.doi.org/10.3389/fnhum.2021.780884
_version_ 1784633747897843712
author Tesen, Hirofumi
Watanabe, Keita
Okamoto, Naomichi
Ikenouchi, Atsuko
Igata, Ryohei
Konishi, Yuki
Kakeda, Shingo
Yoshimura, Reiji
author_facet Tesen, Hirofumi
Watanabe, Keita
Okamoto, Naomichi
Ikenouchi, Atsuko
Igata, Ryohei
Konishi, Yuki
Kakeda, Shingo
Yoshimura, Reiji
author_sort Tesen, Hirofumi
collection PubMed
description We examined amygdala subregion volumes in patients with a first episode of major depression (MD) and in healthy subjects. Covariate-adjusted linear regression was performed to compare the MD and healthy groups, and adjustments for age, gender, and total estimated intracranial volume showed no differences in amygdala subregion volumes between the healthy and MD groups. Within the MD group, we examined the association between amygdala subregion volume and the 17-item Hamilton Rating Scale for Depression (HAMD) score and the HAMD subscale score, and found no association in the left amygdala. In the right amygdala, however, there was an inverse linear association between the HAMD total and the HAMD core and lateral nucleus and anterior-amygdaloid-regions. Furthermore, an inverse linear association was seen between the HAMD psychic and the lateral nucleus, anterior-amygdaloid-regions, transition, and whole amygdala. The findings of this study suggest that the severity of MD and some symptoms of MD are associated with right amygdala volume. There have been few reports on the relationship between MD and amygdala subregional volume, and further research is needed to accumulate more data for further validation.
format Online
Article
Text
id pubmed-8762364
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87623642022-01-18 Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression Tesen, Hirofumi Watanabe, Keita Okamoto, Naomichi Ikenouchi, Atsuko Igata, Ryohei Konishi, Yuki Kakeda, Shingo Yoshimura, Reiji Front Hum Neurosci Neuroscience We examined amygdala subregion volumes in patients with a first episode of major depression (MD) and in healthy subjects. Covariate-adjusted linear regression was performed to compare the MD and healthy groups, and adjustments for age, gender, and total estimated intracranial volume showed no differences in amygdala subregion volumes between the healthy and MD groups. Within the MD group, we examined the association between amygdala subregion volume and the 17-item Hamilton Rating Scale for Depression (HAMD) score and the HAMD subscale score, and found no association in the left amygdala. In the right amygdala, however, there was an inverse linear association between the HAMD total and the HAMD core and lateral nucleus and anterior-amygdaloid-regions. Furthermore, an inverse linear association was seen between the HAMD psychic and the lateral nucleus, anterior-amygdaloid-regions, transition, and whole amygdala. The findings of this study suggest that the severity of MD and some symptoms of MD are associated with right amygdala volume. There have been few reports on the relationship between MD and amygdala subregional volume, and further research is needed to accumulate more data for further validation. Frontiers Media S.A. 2022-01-03 /pmc/articles/PMC8762364/ /pubmed/35046783 http://dx.doi.org/10.3389/fnhum.2021.780884 Text en Copyright © 2022 Tesen, Watanabe, Okamoto, Ikenouchi, Igata, Konishi, Kakeda and Yoshimura. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tesen, Hirofumi
Watanabe, Keita
Okamoto, Naomichi
Ikenouchi, Atsuko
Igata, Ryohei
Konishi, Yuki
Kakeda, Shingo
Yoshimura, Reiji
Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression
title Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression
title_full Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression
title_fullStr Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression
title_full_unstemmed Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression
title_short Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression
title_sort volume of amygdala subregions and clinical manifestations in patients with first-episode, drug-naïve major depression
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762364/
https://www.ncbi.nlm.nih.gov/pubmed/35046783
http://dx.doi.org/10.3389/fnhum.2021.780884
work_keys_str_mv AT tesenhirofumi volumeofamygdalasubregionsandclinicalmanifestationsinpatientswithfirstepisodedrugnaivemajordepression
AT watanabekeita volumeofamygdalasubregionsandclinicalmanifestationsinpatientswithfirstepisodedrugnaivemajordepression
AT okamotonaomichi volumeofamygdalasubregionsandclinicalmanifestationsinpatientswithfirstepisodedrugnaivemajordepression
AT ikenouchiatsuko volumeofamygdalasubregionsandclinicalmanifestationsinpatientswithfirstepisodedrugnaivemajordepression
AT igataryohei volumeofamygdalasubregionsandclinicalmanifestationsinpatientswithfirstepisodedrugnaivemajordepression
AT konishiyuki volumeofamygdalasubregionsandclinicalmanifestationsinpatientswithfirstepisodedrugnaivemajordepression
AT kakedashingo volumeofamygdalasubregionsandclinicalmanifestationsinpatientswithfirstepisodedrugnaivemajordepression
AT yoshimurareiji volumeofamygdalasubregionsandclinicalmanifestationsinpatientswithfirstepisodedrugnaivemajordepression