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A natural product targets BRD4 to inhibit phase separation and gene transcription

The BET-bromodomain protein BRD4 uses two bromodomains to target acetyl-histones and other domains to recruit P-TEFb and other transcription factors to stimulate transcription of proto-oncogenes and key cell identity genes. Recent studies show that its ability to form phase-separated condensates tha...

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Detalles Bibliográficos
Autores principales:	Wang, Cong, Lu, Huasong, Liu, Xiangzhong, Gao, Xiang, Tian, Wenjing, Chen, Haifeng, Xue, Yuhua, Zhou, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762392/ https://www.ncbi.nlm.nih.gov/pubmed/35072011 http://dx.doi.org/10.1016/j.isci.2021.103719

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