Cargando…
Cytosolic adaptation to mitochondria-induced proteostatic stress causes progressive muscle wasting
Mitochondrial dysfunction causes muscle wasting in many diseases and probably also during aging. The underlying mechanism is poorly understood. We generated transgenic mice with unbalanced mitochondrial protein loading and import, by moderately overexpressing the nuclear-encoded adenine nucleotide t...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762400/ https://www.ncbi.nlm.nih.gov/pubmed/35072007 http://dx.doi.org/10.1016/j.isci.2021.103715 |