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Detection of indoleamine 2,3-dioxygenase 1-expressing cells in canine normal and tumor tissues

Cancer immunotherapy is a novel cancer treatment for canine tumors. Indoleamine 2,3-dioxygenase 1 (IDO1) is overexpressed in some human tumors and inhibits antitumor immunity. In this study, we comprehensively evaluated expression pattern of IDO1 and the nature of IDO1-expressing cells in canine nor...

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Autores principales: IKEDA, Namiko, KATO, Daiki, TSUBOI, Masaya, YOSHITAKE, Ryohei, ETO, Shotaro, YOSHIMOTO, Sho, SHINADA, Masahiro, KAMOTO, Satoshi, HASHIMOTO, Yuko, TAKAHASHI, Yousuke, CHAMBERS, James, UCHIDA, Kazuyuki, NISHIMURA, Ryohei, NAKAGAWA, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762412/
https://www.ncbi.nlm.nih.gov/pubmed/34690223
http://dx.doi.org/10.1292/jvms.21-0217
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author IKEDA, Namiko
KATO, Daiki
TSUBOI, Masaya
YOSHITAKE, Ryohei
ETO, Shotaro
YOSHIMOTO, Sho
SHINADA, Masahiro
KAMOTO, Satoshi
HASHIMOTO, Yuko
TAKAHASHI, Yousuke
CHAMBERS, James
UCHIDA, Kazuyuki
NISHIMURA, Ryohei
NAKAGAWA, Takayuki
author_facet IKEDA, Namiko
KATO, Daiki
TSUBOI, Masaya
YOSHITAKE, Ryohei
ETO, Shotaro
YOSHIMOTO, Sho
SHINADA, Masahiro
KAMOTO, Satoshi
HASHIMOTO, Yuko
TAKAHASHI, Yousuke
CHAMBERS, James
UCHIDA, Kazuyuki
NISHIMURA, Ryohei
NAKAGAWA, Takayuki
author_sort IKEDA, Namiko
collection PubMed
description Cancer immunotherapy is a novel cancer treatment for canine tumors. Indoleamine 2,3-dioxygenase 1 (IDO1) is overexpressed in some human tumors and inhibits antitumor immunity. In this study, we comprehensively evaluated expression pattern of IDO1 and the nature of IDO1-expressing cells in canine normal and tumor tissues. In normal tissue samples, IDO1 expression was detected only in the lymph nodes, spleen, tonsil tissues, and colon tissues. In contrast, IDO1-positive tumor cells were observed in several tumor tissue types. This is the first study to evaluate IDO1 expression in canine normal and tumor tissues, and the results suggest that IDO1 is a promising target for novel cancer immunotherapy in dogs with tumors.
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spelling pubmed-87624122022-01-21 Detection of indoleamine 2,3-dioxygenase 1-expressing cells in canine normal and tumor tissues IKEDA, Namiko KATO, Daiki TSUBOI, Masaya YOSHITAKE, Ryohei ETO, Shotaro YOSHIMOTO, Sho SHINADA, Masahiro KAMOTO, Satoshi HASHIMOTO, Yuko TAKAHASHI, Yousuke CHAMBERS, James UCHIDA, Kazuyuki NISHIMURA, Ryohei NAKAGAWA, Takayuki J Vet Med Sci Surgery Cancer immunotherapy is a novel cancer treatment for canine tumors. Indoleamine 2,3-dioxygenase 1 (IDO1) is overexpressed in some human tumors and inhibits antitumor immunity. In this study, we comprehensively evaluated expression pattern of IDO1 and the nature of IDO1-expressing cells in canine normal and tumor tissues. In normal tissue samples, IDO1 expression was detected only in the lymph nodes, spleen, tonsil tissues, and colon tissues. In contrast, IDO1-positive tumor cells were observed in several tumor tissue types. This is the first study to evaluate IDO1 expression in canine normal and tumor tissues, and the results suggest that IDO1 is a promising target for novel cancer immunotherapy in dogs with tumors. The Japanese Society of Veterinary Science 2021-10-22 2021-12 /pmc/articles/PMC8762412/ /pubmed/34690223 http://dx.doi.org/10.1292/jvms.21-0217 Text en ©2021 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Surgery
IKEDA, Namiko
KATO, Daiki
TSUBOI, Masaya
YOSHITAKE, Ryohei
ETO, Shotaro
YOSHIMOTO, Sho
SHINADA, Masahiro
KAMOTO, Satoshi
HASHIMOTO, Yuko
TAKAHASHI, Yousuke
CHAMBERS, James
UCHIDA, Kazuyuki
NISHIMURA, Ryohei
NAKAGAWA, Takayuki
Detection of indoleamine 2,3-dioxygenase 1-expressing cells in canine normal and tumor tissues
title Detection of indoleamine 2,3-dioxygenase 1-expressing cells in canine normal and tumor tissues
title_full Detection of indoleamine 2,3-dioxygenase 1-expressing cells in canine normal and tumor tissues
title_fullStr Detection of indoleamine 2,3-dioxygenase 1-expressing cells in canine normal and tumor tissues
title_full_unstemmed Detection of indoleamine 2,3-dioxygenase 1-expressing cells in canine normal and tumor tissues
title_short Detection of indoleamine 2,3-dioxygenase 1-expressing cells in canine normal and tumor tissues
title_sort detection of indoleamine 2,3-dioxygenase 1-expressing cells in canine normal and tumor tissues
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762412/
https://www.ncbi.nlm.nih.gov/pubmed/34690223
http://dx.doi.org/10.1292/jvms.21-0217
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