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Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation

OBJECTIVE: Genome-wide association studies identified ORMDL3 as an obesity-related gene, and its expression was negatively correlated with body mass index. However, the precise biological roles of ORMDL3 in obesity and lipid metabolism remain uncharacterized. Here, we investigate the function of ORM...

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Detalles Bibliográficos
Autores principales:	Song, Yu, Zan, Wenying, Qin, Liping, Han, Shuang, Ye, Lili, Wang, Molin, Jiang, Baichun, Fang, Pan, Liu, Qiji, Shao, Changshun, Gong, Yaoqin, Li, Peishan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762460/ https://www.ncbi.nlm.nih.gov/pubmed/34954108 http://dx.doi.org/10.1016/j.molmet.2021.101423

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