BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis

During apoptosis, the BCL‐2‐family protein tBID promotes mitochondrial permeabilization by activating BAX and BAK and by blocking anti‐apoptotic BCL‐2 members. Here, we report that tBID can also mediate mitochondrial permeabilization by itself, resulting in release of cytochrome c and mitochondrial...

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Detalles Bibliográficos
Autores principales: Flores‐Romero, Hector, Hohorst, Lisa, John, Malina, Albert, Marie‐Christine, King, Louise E, Beckmann, Laura, Szabo, Tamas, Hertlein, Vanessa, Luo, Xu, Villunger, Andreas, Frenzel, Lukas P, Kashkar, Hamid, Garcia‐Saez, Ana J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762556/
https://www.ncbi.nlm.nih.gov/pubmed/34931711
http://dx.doi.org/10.15252/embj.2021108690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762556/
https://www.ncbi.nlm.nih.gov/pubmed/34931711
http://dx.doi.org/10.15252/embj.2021108690

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