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Microenvironmental influences on T cell immunity in cancer and inflammation
T cell metabolism is dynamic and highly regulated. While the intrinsic metabolic programs of T cell subsets are integral to their distinct differentiation and functional patterns, the ability of cells to acquire nutrients and cope with hostile microenvironments can limit these pathways. T cells must...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762638/ https://www.ncbi.nlm.nih.gov/pubmed/35039633 http://dx.doi.org/10.1038/s41423-021-00833-2 |
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author | Heintzman, Darren R. Fisher, Emilie L. Rathmell, Jeffrey C. |
author_facet | Heintzman, Darren R. Fisher, Emilie L. Rathmell, Jeffrey C. |
author_sort | Heintzman, Darren R. |
collection | PubMed |
description | T cell metabolism is dynamic and highly regulated. While the intrinsic metabolic programs of T cell subsets are integral to their distinct differentiation and functional patterns, the ability of cells to acquire nutrients and cope with hostile microenvironments can limit these pathways. T cells must function in a wide variety of tissue settings, and how T cells interpret these signals to maintain an appropriate metabolic program for their demands or if metabolic mechanisms of immune suppression restrain immunity is an area of growing importance. Both in inflamed and cancer tissues, a wide range of changes in physical conditions and nutrient availability are now acknowledged to shape immunity. These include fever and increased temperatures, depletion of critical micro and macro-nutrients, and accumulation of inhibitory waste products. Here we review several of these factors and how the tissue microenvironment both shapes and constrains immunity. |
format | Online Article Text |
id | pubmed-8762638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-87626382022-01-18 Microenvironmental influences on T cell immunity in cancer and inflammation Heintzman, Darren R. Fisher, Emilie L. Rathmell, Jeffrey C. Cell Mol Immunol Review Article T cell metabolism is dynamic and highly regulated. While the intrinsic metabolic programs of T cell subsets are integral to their distinct differentiation and functional patterns, the ability of cells to acquire nutrients and cope with hostile microenvironments can limit these pathways. T cells must function in a wide variety of tissue settings, and how T cells interpret these signals to maintain an appropriate metabolic program for their demands or if metabolic mechanisms of immune suppression restrain immunity is an area of growing importance. Both in inflamed and cancer tissues, a wide range of changes in physical conditions and nutrient availability are now acknowledged to shape immunity. These include fever and increased temperatures, depletion of critical micro and macro-nutrients, and accumulation of inhibitory waste products. Here we review several of these factors and how the tissue microenvironment both shapes and constrains immunity. Nature Publishing Group UK 2022-01-17 2022-03 /pmc/articles/PMC8762638/ /pubmed/35039633 http://dx.doi.org/10.1038/s41423-021-00833-2 Text en © The Author(s), under exclusive licence to CSI and USTC 2022 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Heintzman, Darren R. Fisher, Emilie L. Rathmell, Jeffrey C. Microenvironmental influences on T cell immunity in cancer and inflammation |
title | Microenvironmental influences on T cell immunity in cancer and inflammation |
title_full | Microenvironmental influences on T cell immunity in cancer and inflammation |
title_fullStr | Microenvironmental influences on T cell immunity in cancer and inflammation |
title_full_unstemmed | Microenvironmental influences on T cell immunity in cancer and inflammation |
title_short | Microenvironmental influences on T cell immunity in cancer and inflammation |
title_sort | microenvironmental influences on t cell immunity in cancer and inflammation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762638/ https://www.ncbi.nlm.nih.gov/pubmed/35039633 http://dx.doi.org/10.1038/s41423-021-00833-2 |
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