Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma

PURPOSE: Extracellular matrix stiffening is characteristic of both aging and glaucoma, and acts as a promoter and perpetuator of pathological fibrotic remodeling. Here, we investigate the role of a mechanosensitive transcriptional coactivator, Yes-associated protein (YAP), a downstream effector of m...

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Detalles Bibliográficos
Autores principales: Murphy, Rory, Irnaten, Mustapha, Hopkins, Alan, O'Callaghan, Jeffrey, Stamer, W. Daniel, Clark, Abbot F., Wallace, Deborah, O'Brien, Colm J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Glaucoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762700/
https://www.ncbi.nlm.nih.gov/pubmed/35015027
http://dx.doi.org/10.1167/iovs.63.1.16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762700/
https://www.ncbi.nlm.nih.gov/pubmed/35015027
http://dx.doi.org/10.1167/iovs.63.1.16

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