Cargando…

Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma

PURPOSE: Extracellular matrix stiffening is characteristic of both aging and glaucoma, and acts as a promoter and perpetuator of pathological fibrotic remodeling. Here, we investigate the role of a mechanosensitive transcriptional coactivator, Yes-associated protein (YAP), a downstream effector of m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murphy, Rory, Irnaten, Mustapha, Hopkins, Alan, O'Callaghan, Jeffrey, Stamer, W. Daniel, Clark, Abbot F., Wallace, Deborah, O'Brien, Colm J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Glaucoma
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762700/ https://www.ncbi.nlm.nih.gov/pubmed/35015027 http://dx.doi.org/10.1167/iovs.63.1.16

Ejemplares similares

Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells
por: Kamel, Khalid, et al.
Publicado: (2020)

Calcium-Signalling in Human Glaucoma Lamina Cribrosa Myofibroblasts
por: Irnaten, Mustapha, et al.
Publicado: (2023)

Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma
por: Irnaten, Mustapha, et al.
Publicado: (2020)

Evaluating displacement of lamina cribrosa following glaucoma surgery
por: Krzyżanowska-Berkowska, Patrycja, et al.
Publicado: (2018)

Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma
por: Moghimi, Sasan, et al.
Publicado: (2018)

Lamina Cribrosa Microarchitecture in Monkey Early Experimental Glaucoma: Global Change
por: Reynaud, Juan, et al.
Publicado: (2016)

The Effects of Glaucoma on the Pressure-Induced Strain Response of the Human Lamina Cribrosa
por: Midgett, Dan, et al.
Publicado: (2020)

Comparison of Lamina Cribrosa Morphology in Eyes with Ocular Hypertension and Normal-Tension Glaucoma
por: Kim, Ji-Ah, et al.
Publicado: (2020)

Comparison of Lamina Cribrosa Morphology in Normal Tension Glaucoma and Autosomal-Dominant Optic Atrophy
por: Kim, Gyu-Nam, et al.
Publicado: (2020)

Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells
por: McElnea, Elizabeth M, et al.
Publicado: (2014)

Morphologic Changes in the Lamina Cribrosa Upon Intraocular Pressure Lowering in Patients With Normal Tension Glaucoma
por: Kim, Jeong-Ah, et al.
Publicado: (2022)

Effects of Peripapillary Scleral Stiffening on the Deformation of the Lamina Cribrosa
por: Coudrillier, Baptiste, et al.
Publicado: (2016)

Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases
por: Brazile, Bryn L., et al.
Publicado: (2020)

Differentiation of Nonarteritic Anterior Ischemic Optic Neuropathy from Normal Tension Glaucoma by Comparison of the Lamina Cribrosa
por: Kim, Jeong-Ah, et al.
Publicado: (2020)

Racial Differences in the Association of Anterior Lamina Cribrosa Surface Depth and Glaucoma Severity in the African Descent and Glaucoma Evaluation Study (ADAGES)
por: Girkin, Christopher A., et al.
Publicado: (2019)

Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers
por: Jan, Ning-Jiun, et al.
Publicado: (2017)

In Vivo Measurements of Prelamina and Lamina Cribrosa Biomechanical Properties in Humans
por: Zhang, Liang, et al.
Publicado: (2020)

Lamina Cribrosa Moves Anteriorly After Trabeculectomy in Myopic Eyes
por: Lee, Seung Hyen, et al.
Publicado: (2020)

Racial Differences in the Rate of Change in Anterior Lamina Cribrosa Surface Depth in the African Descent and Glaucoma Evaluation Study
por: Girkin, Christopher A., et al.
Publicado: (2021)

Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams
por: Brazile, Bryn L., et al.
Publicado: (2018)

Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study
por: Luo, Haomin, et al.
Publicado: (2018)

Comparing Acute IOP-Induced Lamina Cribrosa Deformations Premortem and Postmortem
por: Wei, Junchao, et al.
Publicado: (2022)

Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult
por: Voorhees, Andrew P., et al.
Publicado: (2017)

Characterizing the Collagen Network Structure and Pressure-Induced Strains of the Human Lamina Cribrosa
por: Ling, Yik Tung Tracy, et al.
Publicado: (2019)

Under Pressure: Lamina Cribrosa Pore Path Tortuosity in Response to Acute Pressure Modulation
por: Alexopoulos, Palaiologos, et al.
Publicado: (2023)

Morphometric, Hemodynamic, and Biomechanical Factors Influencing Blood Flow and Oxygen Concentration in the Human Lamina Cribrosa
por: Chuangsuwanich, Thanadet, et al.
Publicado: (2020)

So-Called Lamina Cribrosa Defects May Mitigate IOP-Induced Neural Tissue Insult
por: Voorhees, Andrew P., et al.
Publicado: (2020)

Microstructural Deformations Within the Depth of the Lamina Cribrosa in Response to Acute In Vivo Intraocular Pressure Modulation
por: Glidai, Yoav, et al.
Publicado: (2022)

Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues
por: Karimi, Alireza, et al.
Publicado: (2022)

Displacement of the Lamina Cribrosa in Response to Acute Intraocular Pressure Elevation in Normal Individuals of African and European Descent
por: Fazio, Massimo A., et al.
Publicado: (2016)

Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors
por: McElnea, E.M., et al.
Publicado: (2011)

Abnormal corneal properties in osteogenesis imperfecta and glaucoma: a case series
por: Doolan, Emer, et al.
Publicado: (2021)

Effects of Myopia and Glaucoma on the Neural Canal and Lamina Cribrosa Using Optical Coherence Tomography
por: Lee, Sieun, et al.
Publicado: (2023)

Age-Related Changes in Quantitative Strain of Mouse Astrocytic Lamina Cribrosa and Peripapillary Sclera Using Confocal Microscopy in an Explant Model
por: Nguyen, Cathy, et al.
Publicado: (2018)

Variation in the Three-Dimensional Histomorphometry of the Normal Human Optic Nerve Head With Age and Race: Lamina Cribrosa and Peripapillary Scleral Thickness and Position
por: Girkin, Christopher A., et al.
Publicado: (2017)

Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells
por: Kirwan, Ruaidhrí P., et al.
Publicado: (2009)

Biomechanical research into lamina cribrosa in glaucoma
por: Li, Long, et al.
Publicado: (2020)

Defects of the Lamina Cribrosa in High Myopia and Glaucoma
por: Miki, Atsuya, et al.
Publicado: (2015)

Metformin and Glaucoma—Review of Anti-Fibrotic Processes and Bioenergetics
por: Hurley, Daire J., et al.
Publicado: (2021)

Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma
por: Patel, Gaurang C., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lempgoum102mf19jvlasahfqh3