Design of Coibamide A Mimetics with Improved Cellular Bioactivity

[Image: see text] Coibamide A, a cyclic depsipeptide isolated from a Panamanian marine cyanobacterium, shows potent cytotoxic activity via the inhibition of the Sec61 translocon. We designed a coibamide A mimetic in which the ester linkage between MeThr and d-MeAla in coibamide A was replaced with a...

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Detalles Bibliográficos
Autores principales: Kitamura, Takashi, Suzuki, Rikito, Inuki, Shinsuke, Ohno, Hiroaki, McPhail, Kerry L., Oishi, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762706/
https://www.ncbi.nlm.nih.gov/pubmed/35059129
http://dx.doi.org/10.1021/acsmedchemlett.1c00591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762706/
https://www.ncbi.nlm.nih.gov/pubmed/35059129
http://dx.doi.org/10.1021/acsmedchemlett.1c00591

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