Blood-based epigenome-wide analyses of cognitive abilities

BACKGROUND: Blood-based markers of cognitive functioning might provide an accessible way to track neurodegeneration years prior to clinical manifestation of cognitive impairment and dementia. RESULTS: Using blood-based epigenome-wide analyses of general cognitive function, we show that individual di...

Descripción completa

Detalles Bibliográficos
Autores principales: McCartney, Daniel L., Hillary, Robert F., Conole, Eleanor L. S., Banos, Daniel Trejo, Gadd, Danni A., Walker, Rosie M., Nangle, Cliff, Flaig, Robin, Campbell, Archie, Murray, Alison D., Maniega, Susana Muñoz, Valdés-Hernández, María del C., Harris, Mathew A., Bastin, Mark E., Wardlaw, Joanna M., Harris, Sarah E., Porteous, David J., Tucker-Drob, Elliot M., McIntosh, Andrew M., Evans, Kathryn L., Deary, Ian J., Cox, Simon R., Robinson, Matthew R., Marioni, Riccardo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762878/
https://www.ncbi.nlm.nih.gov/pubmed/35039062
http://dx.doi.org/10.1186/s13059-021-02596-5
Descripción
Sumario:BACKGROUND: Blood-based markers of cognitive functioning might provide an accessible way to track neurodegeneration years prior to clinical manifestation of cognitive impairment and dementia. RESULTS: Using blood-based epigenome-wide analyses of general cognitive function, we show that individual differences in DNA methylation (DNAm) explain 35.0% of the variance in general cognitive function (g). A DNAm predictor explains ~4% of the variance, independently of a polygenic score, in two external cohorts. It also associates with circulating levels of neurology- and inflammation-related proteins, global brain imaging metrics, and regional cortical volumes. CONCLUSIONS: As sample sizes increase, the ability to assess cognitive function from DNAm data may be informative in settings where cognitive testing is unreliable or unavailable. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-021-02596-5.

Ejemplares similares