Microsatellite instability is biased in Amsterdam II-defined Lynch-related cancer cases with family history but is rare in other cancers: a summary of 1000 analyses

BACKGROUND: Microsatellite instability (MSI) is a key marker for predicting the response of immune checkpoint inhibitors (ICIs) and for screening Lynch syndrome (LS). AIM: This study aimed to see the characteristics of cancers with high level of MSI (MSI-H) in genetic medicine and precision medicine...

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Detalles Bibliográficos
Autores principales: Matsubayashi, Hiroyuki, Higashigawa, Satomi, Kiyozumi, Yoshimi, Oishi, Takuma, Sasaki, Keiko, Ishiwatari, Hirotoshi, Imai, Kenichiro, Hotta, Kinichi, Yabuuchi, Yohei, Ishikawa, Kazuma, Satoh, Tatsunori, Ono, Hiroyuki, Todaka, Akiko, Kawakami, Takeshi, Shirasu, Hiromichi, Yasui, Hirofumi, Sugiura, Teichi, Uesaka, Katsuhiko, Kagawa, Hiroyasu, Shiomi, Akio, Kado, Nobuhiro, Hirashima, Yasuyuki, Kiyohara, Yoshio, Bando, Etsuro, Niwakawa, Masashi, Nishimura, Seiichiro, Aramaki, Takeshi, Mamesaya, Nobuaki, Kenmotsu, Hirotsugu, Horiuchi, Yasue, Serizawa, Masakuni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762879/
https://www.ncbi.nlm.nih.gov/pubmed/35039004
http://dx.doi.org/10.1186/s12885-022-09172-5

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