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Remarkably Low KIR and HLA Diversity in Amerindians Reveals Signatures of Strong Purifying Selection Shaping the Centromeric KIR Region

The killer-cell immunoglobulin-like receptors (KIR) recognize human leukocyte antigen (HLA) molecules to regulate the cytotoxic and inflammatory responses of natural killer cells. KIR genes are encoded by a rapidly evolving gene family on chromosome 19 and present an unusual variation of presence an...

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Detalles Bibliográficos
Autores principales:	de Brito Vargas, Luciana, Beltrame, Marcia H, Ho, Brenda, Marin, Wesley M, Dandekar, Ravi, Montero-Martín, Gonzalo, Fernández-Viña, Marcelo A, Hurtado, A Magdalena, Hill, Kim R, Tsuneto, Luiza T, Hutz, Mara H, Salzano, Francisco M, Petzl-Erler, Maria Luiza, Hollenbach, Jill A, Augusto, Danillo G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Discoveries
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763117/ https://www.ncbi.nlm.nih.gov/pubmed/34633459 http://dx.doi.org/10.1093/molbev/msab298

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