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Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population

OBJECTIVE: To investigate the differential ability of the “Test Relaties Abstracte Concepten” (TRACE), a Dutch test for abstract semantic knowledge, in frontotemporal dementia (FTD). METHODS: The TRACE was administered in patients with behavioral variant FTD (bvFTD; n = 16), nonfluent variant (nfvPP...

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Autores principales: Poos, J M, van den Berg, E, Visch-Brink, E, Eikelboom, W S, Franzen, S, van Hemmen, J, Pijnenburg, Y A L, Satoer, D, Dopper, E G P, van Swieten, J C, Papma, J M, Seelaar, H, Jiskoot, L C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763124/
https://www.ncbi.nlm.nih.gov/pubmed/33856423
http://dx.doi.org/10.1093/arclin/acab022
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author Poos, J M
van den Berg, E
Visch-Brink, E
Eikelboom, W S
Franzen, S
van Hemmen, J
Pijnenburg, Y A L
Satoer, D
Dopper, E G P
van Swieten, J C
Papma, J M
Seelaar, H
Jiskoot, L C
author_facet Poos, J M
van den Berg, E
Visch-Brink, E
Eikelboom, W S
Franzen, S
van Hemmen, J
Pijnenburg, Y A L
Satoer, D
Dopper, E G P
van Swieten, J C
Papma, J M
Seelaar, H
Jiskoot, L C
author_sort Poos, J M
collection PubMed
description OBJECTIVE: To investigate the differential ability of the “Test Relaties Abstracte Concepten” (TRACE), a Dutch test for abstract semantic knowledge, in frontotemporal dementia (FTD). METHODS: The TRACE was administered in patients with behavioral variant FTD (bvFTD; n = 16), nonfluent variant (nfvPPA; n = 10), logopenic variant (lvPPA; n = 10), and semantic variant primary progressive aphasia (svPPA; n = 9), and controls (n = 59). We examined group differences, performed correlational analyses with other neuropsychological tests and investigated discriminative ability. We compared the TRACE with a semantic association test for concrete stimuli (SAT). RESULTS: All patient groups, except nfvPPA, performed worse on the TRACE than controls (p < .01). svPPA patients performed worse than the other patient groups (p < .05). The TRACE discriminated well between patient groups, except nfvPPA, versus controls (all p < .01) and between svPPA versus other patient groups with high sensitivity (75–100%) and specificity (86%–92%). In bvFTD and nfvPPA the TRACE correlated with language tests (ρ > 0.6), whereas in svPPA the concrete task correlated (ρ ≥ 0.75) with language tests. Patients with bvFTD, nfvPPA and lvPPA performed lower on the TRACE than the SAT (p < .05), whereas patients with svPPA were equally impaired on both tasks (p = .2). DISCUSSION: We demonstrated impaired abstract semantic knowledge in patients with bvFTD, lvPPA, and svPPA, but not nfvPPA, with svPPA patients performing worse than the other subtypes. The TRACE was a good classifier between each patient group versus controls and between svPPA versus other patient groups. This highlights the value of incorporating semantic tests with abstract stimuli into standard neuropsychological assessment for early differential diagnosis of FTD subtypes.
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spelling pubmed-87631242022-01-18 Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population Poos, J M van den Berg, E Visch-Brink, E Eikelboom, W S Franzen, S van Hemmen, J Pijnenburg, Y A L Satoer, D Dopper, E G P van Swieten, J C Papma, J M Seelaar, H Jiskoot, L C Arch Clin Neuropsychol Original Empirical Article OBJECTIVE: To investigate the differential ability of the “Test Relaties Abstracte Concepten” (TRACE), a Dutch test for abstract semantic knowledge, in frontotemporal dementia (FTD). METHODS: The TRACE was administered in patients with behavioral variant FTD (bvFTD; n = 16), nonfluent variant (nfvPPA; n = 10), logopenic variant (lvPPA; n = 10), and semantic variant primary progressive aphasia (svPPA; n = 9), and controls (n = 59). We examined group differences, performed correlational analyses with other neuropsychological tests and investigated discriminative ability. We compared the TRACE with a semantic association test for concrete stimuli (SAT). RESULTS: All patient groups, except nfvPPA, performed worse on the TRACE than controls (p < .01). svPPA patients performed worse than the other patient groups (p < .05). The TRACE discriminated well between patient groups, except nfvPPA, versus controls (all p < .01) and between svPPA versus other patient groups with high sensitivity (75–100%) and specificity (86%–92%). In bvFTD and nfvPPA the TRACE correlated with language tests (ρ > 0.6), whereas in svPPA the concrete task correlated (ρ ≥ 0.75) with language tests. Patients with bvFTD, nfvPPA and lvPPA performed lower on the TRACE than the SAT (p < .05), whereas patients with svPPA were equally impaired on both tasks (p = .2). DISCUSSION: We demonstrated impaired abstract semantic knowledge in patients with bvFTD, lvPPA, and svPPA, but not nfvPPA, with svPPA patients performing worse than the other subtypes. The TRACE was a good classifier between each patient group versus controls and between svPPA versus other patient groups. This highlights the value of incorporating semantic tests with abstract stimuli into standard neuropsychological assessment for early differential diagnosis of FTD subtypes. Oxford University Press 2021-04-15 /pmc/articles/PMC8763124/ /pubmed/33856423 http://dx.doi.org/10.1093/arclin/acab022 Text en © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Empirical Article
Poos, J M
van den Berg, E
Visch-Brink, E
Eikelboom, W S
Franzen, S
van Hemmen, J
Pijnenburg, Y A L
Satoer, D
Dopper, E G P
van Swieten, J C
Papma, J M
Seelaar, H
Jiskoot, L C
Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population
title Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population
title_full Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population
title_fullStr Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population
title_full_unstemmed Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population
title_short Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population
title_sort exploring abstract semantic associations in the frontotemporal dementia spectrum in a dutch population
topic Original Empirical Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763124/
https://www.ncbi.nlm.nih.gov/pubmed/33856423
http://dx.doi.org/10.1093/arclin/acab022
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