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Deep Learning Algorithm Trained on Brain Magnetic Resonance Images and Clinical Data to Predict Motor Outcomes of Patients With Corona Radiata Infarct

The early and accurate prediction of the extent of long-term motor recovery is important for establishing specific rehabilitation strategies for stroke patients. Using clinical parameters and brain magnetic resonance images as inputs, we developed a deep learning algorithm to increase the prediction...

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Autores principales: Kim, Jeoung Kun, Chang, Min Cheol, Park, Donghwi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763312/
https://www.ncbi.nlm.nih.gov/pubmed/35046770
http://dx.doi.org/10.3389/fnins.2021.795553
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author Kim, Jeoung Kun
Chang, Min Cheol
Park, Donghwi
author_facet Kim, Jeoung Kun
Chang, Min Cheol
Park, Donghwi
author_sort Kim, Jeoung Kun
collection PubMed
description The early and accurate prediction of the extent of long-term motor recovery is important for establishing specific rehabilitation strategies for stroke patients. Using clinical parameters and brain magnetic resonance images as inputs, we developed a deep learning algorithm to increase the prediction accuracy of long-term motor outcomes in patients with corona radiata (CR) infarct. Using brain magnetic resonance images and clinical data obtained soon after CR infarct, we developed an integrated algorithm to predict hand function and ambulatory outcomes of the patient 6 months after onset. To develop and evaluate the algorithm, we retrospectively recruited 221 patients with CR infarct. The area under the curve of the validation set of the integrated modified Brunnstrom classification prediction model was 0.891 with 95% confidence interval (0.814–0.967) and that of the integrated functional ambulatory category prediction model was 0.919, with 95% confidence interval (0.842–0.995). We demonstrated that an integrated algorithm trained using patients’ clinical data and brain magnetic resonance images obtained soon after CR infarct can promote the accurate prediction of long-term hand function and ambulatory outcomes. Future efforts will be devoted to finding more appropriate input variables to further increase the accuracy of deep learning models in clinical applications.
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spelling pubmed-87633122022-01-18 Deep Learning Algorithm Trained on Brain Magnetic Resonance Images and Clinical Data to Predict Motor Outcomes of Patients With Corona Radiata Infarct Kim, Jeoung Kun Chang, Min Cheol Park, Donghwi Front Neurosci Neuroscience The early and accurate prediction of the extent of long-term motor recovery is important for establishing specific rehabilitation strategies for stroke patients. Using clinical parameters and brain magnetic resonance images as inputs, we developed a deep learning algorithm to increase the prediction accuracy of long-term motor outcomes in patients with corona radiata (CR) infarct. Using brain magnetic resonance images and clinical data obtained soon after CR infarct, we developed an integrated algorithm to predict hand function and ambulatory outcomes of the patient 6 months after onset. To develop and evaluate the algorithm, we retrospectively recruited 221 patients with CR infarct. The area under the curve of the validation set of the integrated modified Brunnstrom classification prediction model was 0.891 with 95% confidence interval (0.814–0.967) and that of the integrated functional ambulatory category prediction model was 0.919, with 95% confidence interval (0.842–0.995). We demonstrated that an integrated algorithm trained using patients’ clinical data and brain magnetic resonance images obtained soon after CR infarct can promote the accurate prediction of long-term hand function and ambulatory outcomes. Future efforts will be devoted to finding more appropriate input variables to further increase the accuracy of deep learning models in clinical applications. Frontiers Media S.A. 2022-01-03 /pmc/articles/PMC8763312/ /pubmed/35046770 http://dx.doi.org/10.3389/fnins.2021.795553 Text en Copyright © 2022 Kim, Chang and Park. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kim, Jeoung Kun
Chang, Min Cheol
Park, Donghwi
Deep Learning Algorithm Trained on Brain Magnetic Resonance Images and Clinical Data to Predict Motor Outcomes of Patients With Corona Radiata Infarct
title Deep Learning Algorithm Trained on Brain Magnetic Resonance Images and Clinical Data to Predict Motor Outcomes of Patients With Corona Radiata Infarct
title_full Deep Learning Algorithm Trained on Brain Magnetic Resonance Images and Clinical Data to Predict Motor Outcomes of Patients With Corona Radiata Infarct
title_fullStr Deep Learning Algorithm Trained on Brain Magnetic Resonance Images and Clinical Data to Predict Motor Outcomes of Patients With Corona Radiata Infarct
title_full_unstemmed Deep Learning Algorithm Trained on Brain Magnetic Resonance Images and Clinical Data to Predict Motor Outcomes of Patients With Corona Radiata Infarct
title_short Deep Learning Algorithm Trained on Brain Magnetic Resonance Images and Clinical Data to Predict Motor Outcomes of Patients With Corona Radiata Infarct
title_sort deep learning algorithm trained on brain magnetic resonance images and clinical data to predict motor outcomes of patients with corona radiata infarct
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763312/
https://www.ncbi.nlm.nih.gov/pubmed/35046770
http://dx.doi.org/10.3389/fnins.2021.795553
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