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Brain Imaging Biomarkers for Chronic Pain

The prevalence of chronic pain has reached epidemic levels. In addition to personal suffering chronic pain is associated with psychiatric and medical co-morbidities, notably substance misuse, and a huge a societal cost amounting to hundreds of billions of dollars annually in medical cost, lost wages...

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Detalles Bibliográficos
Autores principales: Zhang, Zhengwu, Gewandter, Jennifer S., Geha, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763372/
https://www.ncbi.nlm.nih.gov/pubmed/35046881
http://dx.doi.org/10.3389/fneur.2021.734821
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author Zhang, Zhengwu
Gewandter, Jennifer S.
Geha, Paul
author_facet Zhang, Zhengwu
Gewandter, Jennifer S.
Geha, Paul
author_sort Zhang, Zhengwu
collection PubMed
description The prevalence of chronic pain has reached epidemic levels. In addition to personal suffering chronic pain is associated with psychiatric and medical co-morbidities, notably substance misuse, and a huge a societal cost amounting to hundreds of billions of dollars annually in medical cost, lost wages, and productivity. Chronic pain does not have a cure or quantitative diagnostic or prognostic tools. In this manuscript we provide evidence that this situation is about to change. We first start by summarizing our current understanding of the role of the brain in the pathogenesis of chronic pain. We particularly focus on the concept of learning in the emergence of chronic pain, and the implication of the limbic brain circuitry and dopaminergic signaling, which underly emotional learning and decision making, in this process. Next, we summarize data from our labs and from other groups on the latest brain imaging findings in different chronic pain conditions focusing on results with significant potential for translation into clinical applications. The gaps in the study of chronic pain and brain imaging are highlighted in throughout the overview. Finally, we conclude by discussing the costs and benefits of using brain biomarkers of chronic pain and compare to other potential markers.
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spelling pubmed-87633722022-01-18 Brain Imaging Biomarkers for Chronic Pain Zhang, Zhengwu Gewandter, Jennifer S. Geha, Paul Front Neurol Neurology The prevalence of chronic pain has reached epidemic levels. In addition to personal suffering chronic pain is associated with psychiatric and medical co-morbidities, notably substance misuse, and a huge a societal cost amounting to hundreds of billions of dollars annually in medical cost, lost wages, and productivity. Chronic pain does not have a cure or quantitative diagnostic or prognostic tools. In this manuscript we provide evidence that this situation is about to change. We first start by summarizing our current understanding of the role of the brain in the pathogenesis of chronic pain. We particularly focus on the concept of learning in the emergence of chronic pain, and the implication of the limbic brain circuitry and dopaminergic signaling, which underly emotional learning and decision making, in this process. Next, we summarize data from our labs and from other groups on the latest brain imaging findings in different chronic pain conditions focusing on results with significant potential for translation into clinical applications. The gaps in the study of chronic pain and brain imaging are highlighted in throughout the overview. Finally, we conclude by discussing the costs and benefits of using brain biomarkers of chronic pain and compare to other potential markers. Frontiers Media S.A. 2022-01-03 /pmc/articles/PMC8763372/ /pubmed/35046881 http://dx.doi.org/10.3389/fneur.2021.734821 Text en Copyright © 2022 Zhang, Gewandter and Geha. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Zhang, Zhengwu
Gewandter, Jennifer S.
Geha, Paul
Brain Imaging Biomarkers for Chronic Pain
title Brain Imaging Biomarkers for Chronic Pain
title_full Brain Imaging Biomarkers for Chronic Pain
title_fullStr Brain Imaging Biomarkers for Chronic Pain
title_full_unstemmed Brain Imaging Biomarkers for Chronic Pain
title_short Brain Imaging Biomarkers for Chronic Pain
title_sort brain imaging biomarkers for chronic pain
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763372/
https://www.ncbi.nlm.nih.gov/pubmed/35046881
http://dx.doi.org/10.3389/fneur.2021.734821
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