The Glutathione Metabolite γ-Glutamyl-Glutamate Partially Activates Glutamate NMDA Receptors in Central Neurons With Higher Efficacy for GluN2B-Containing Receptors

Gamma-L-glutamyl-L-glutamate (γ-Glu-Glu) was synthetized and further characterized for its activity on cultured neurons. We observed that γ-Glu-Glu elicited excitatory effects on neurons likely by activating mainly the N-methyl-D-aspartate (NMDA) receptors. These effects were dependent on the integr...

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Detalles Bibliográficos
Autores principales: Sebih, Fatiha, Mokrane, Nawfel, Fontanel, Pierre, Kayatekin, Mete, Kaabeche, Mahira, Guiramand, Janique, Cohen-Solal, Catherine, Cens, Thierry, Rousset, Matthieu, Charnet, Pierre, De Jésus Ferreira, Marie-Céleste, Thibaud, Jean-Baptiste, Ménard, Claudine, Cantel, Sonia, Rolland, Valérie, Vignes, Michel, Roussel, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763386/
https://www.ncbi.nlm.nih.gov/pubmed/35046818
http://dx.doi.org/10.3389/fphar.2021.794680

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