Salvage Therapy in Early Relapse of T-Lymphoblastic Leukemia/Lymphoma Using Daratumumab/Nelarabine Combination: Two Consecutive Cases

Treatment of early relapses of T lymphoblastic leukemia/lymphoma is often unsuccessful. We tested an experimental regimen containing daratumumab and nelarabine in two young patients with early relapses of T lymphoblastic lymphoma and T-ALL, respectively. Both patients achieved a deep complete remiss...

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Autores principales: Molle, Ingolf, Petruskevicius, Irma, Kamper, Peter, d'Amore, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763564/
https://www.ncbi.nlm.nih.gov/pubmed/35047223
http://dx.doi.org/10.1155/2022/9722787
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author Molle, Ingolf
Petruskevicius, Irma
Kamper, Peter
d'Amore, Francesco
author_facet Molle, Ingolf
Petruskevicius, Irma
Kamper, Peter
d'Amore, Francesco
author_sort Molle, Ingolf
collection PubMed
description Treatment of early relapses of T lymphoblastic leukemia/lymphoma is often unsuccessful. We tested an experimental regimen containing daratumumab and nelarabine in two young patients with early relapses of T lymphoblastic lymphoma and T-ALL, respectively. Both patients achieved a deep complete remission. Combining daratumumab with chemotherapy may have a role in relapsing T lymphoblastic leukemia/lymphoma.
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spelling pubmed-87635642022-01-18 Salvage Therapy in Early Relapse of T-Lymphoblastic Leukemia/Lymphoma Using Daratumumab/Nelarabine Combination: Two Consecutive Cases Molle, Ingolf Petruskevicius, Irma Kamper, Peter d'Amore, Francesco Case Rep Hematol Case Report Treatment of early relapses of T lymphoblastic leukemia/lymphoma is often unsuccessful. We tested an experimental regimen containing daratumumab and nelarabine in two young patients with early relapses of T lymphoblastic lymphoma and T-ALL, respectively. Both patients achieved a deep complete remission. Combining daratumumab with chemotherapy may have a role in relapsing T lymphoblastic leukemia/lymphoma. Hindawi 2022-01-10 /pmc/articles/PMC8763564/ /pubmed/35047223 http://dx.doi.org/10.1155/2022/9722787 Text en Copyright © 2022 Ingolf Molle et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Molle, Ingolf
Petruskevicius, Irma
Kamper, Peter
d'Amore, Francesco
Salvage Therapy in Early Relapse of T-Lymphoblastic Leukemia/Lymphoma Using Daratumumab/Nelarabine Combination: Two Consecutive Cases
title Salvage Therapy in Early Relapse of T-Lymphoblastic Leukemia/Lymphoma Using Daratumumab/Nelarabine Combination: Two Consecutive Cases
title_full Salvage Therapy in Early Relapse of T-Lymphoblastic Leukemia/Lymphoma Using Daratumumab/Nelarabine Combination: Two Consecutive Cases
title_fullStr Salvage Therapy in Early Relapse of T-Lymphoblastic Leukemia/Lymphoma Using Daratumumab/Nelarabine Combination: Two Consecutive Cases
title_full_unstemmed Salvage Therapy in Early Relapse of T-Lymphoblastic Leukemia/Lymphoma Using Daratumumab/Nelarabine Combination: Two Consecutive Cases
title_short Salvage Therapy in Early Relapse of T-Lymphoblastic Leukemia/Lymphoma Using Daratumumab/Nelarabine Combination: Two Consecutive Cases
title_sort salvage therapy in early relapse of t-lymphoblastic leukemia/lymphoma using daratumumab/nelarabine combination: two consecutive cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763564/
https://www.ncbi.nlm.nih.gov/pubmed/35047223
http://dx.doi.org/10.1155/2022/9722787
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AT kamperpeter salvagetherapyinearlyrelapseoftlymphoblasticleukemialymphomausingdaratumumabnelarabinecombinationtwoconsecutivecases
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