Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease

Stem rot disease caused by Sclerotium rolfsii is one of the destructive diseases in peanut and poses a big risk to peanut production. Current fungicides in the market have not provided satisfactory control efficacy and thus called for novel fungicides with different structures as an alternative trea...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Yihui, Yang, Jun, Yang, Dangwei, Qin, Guangyu, Zu, Junhuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763808/
https://www.ncbi.nlm.nih.gov/pubmed/35058889
http://dx.doi.org/10.3389/fmicb.2021.728173
_version_ 1784634032223420416
author Ma, Yihui
Yang, Jun
Yang, Dangwei
Qin, Guangyu
Zu, Junhuai
author_facet Ma, Yihui
Yang, Jun
Yang, Dangwei
Qin, Guangyu
Zu, Junhuai
author_sort Ma, Yihui
collection PubMed
description Stem rot disease caused by Sclerotium rolfsii is one of the destructive diseases in peanut and poses a big risk to peanut production. Current fungicides in the market have not provided satisfactory control efficacy and thus called for novel fungicides with different structures as an alternative treatment strategy. Our previously developed phenylpyrazole compound 3c demonstrated modest inhibitory effect against S. rolfsii. The following structure modification identified an unreported compound 6, which bears a 3-chloropyridinyl moiety as the most prominent derivative with an IC(50) of 12 μg/ml in potato dextrose agar (PDA) assay, higher than those of 0.8 and 1.8 μg/ml associated with thifluzamide and tebuconazole, respectively. However, compound 6 showed similar controlling effects to those of thifluzamide and tebuconazole in field study. This study underscores the potential of 1,5-diaryl-pyrazole-3-formate as an antifungal candidate for stem rot disease management.
format Online
Article
Text
id pubmed-8763808
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87638082022-01-19 Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease Ma, Yihui Yang, Jun Yang, Dangwei Qin, Guangyu Zu, Junhuai Front Microbiol Microbiology Stem rot disease caused by Sclerotium rolfsii is one of the destructive diseases in peanut and poses a big risk to peanut production. Current fungicides in the market have not provided satisfactory control efficacy and thus called for novel fungicides with different structures as an alternative treatment strategy. Our previously developed phenylpyrazole compound 3c demonstrated modest inhibitory effect against S. rolfsii. The following structure modification identified an unreported compound 6, which bears a 3-chloropyridinyl moiety as the most prominent derivative with an IC(50) of 12 μg/ml in potato dextrose agar (PDA) assay, higher than those of 0.8 and 1.8 μg/ml associated with thifluzamide and tebuconazole, respectively. However, compound 6 showed similar controlling effects to those of thifluzamide and tebuconazole in field study. This study underscores the potential of 1,5-diaryl-pyrazole-3-formate as an antifungal candidate for stem rot disease management. Frontiers Media S.A. 2022-01-04 /pmc/articles/PMC8763808/ /pubmed/35058889 http://dx.doi.org/10.3389/fmicb.2021.728173 Text en Copyright © 2022 Ma, Yang, Yang, Qin and Zu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Ma, Yihui
Yang, Jun
Yang, Dangwei
Qin, Guangyu
Zu, Junhuai
Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease
title Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease
title_full Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease
title_fullStr Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease
title_full_unstemmed Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease
title_short Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease
title_sort development of 1,5-diaryl-pyrazole-3-formate analogs as antifungal pesticides and their application in controlling peanut stem rot disease
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763808/
https://www.ncbi.nlm.nih.gov/pubmed/35058889
http://dx.doi.org/10.3389/fmicb.2021.728173
work_keys_str_mv AT mayihui developmentof15diarylpyrazole3formateanalogsasantifungalpesticidesandtheirapplicationincontrollingpeanutstemrotdisease
AT yangjun developmentof15diarylpyrazole3formateanalogsasantifungalpesticidesandtheirapplicationincontrollingpeanutstemrotdisease
AT yangdangwei developmentof15diarylpyrazole3formateanalogsasantifungalpesticidesandtheirapplicationincontrollingpeanutstemrotdisease
AT qinguangyu developmentof15diarylpyrazole3formateanalogsasantifungalpesticidesandtheirapplicationincontrollingpeanutstemrotdisease
AT zujunhuai developmentof15diarylpyrazole3formateanalogsasantifungalpesticidesandtheirapplicationincontrollingpeanutstemrotdisease

Ejemplares similares