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HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages

Overactivated inflammation and catabolism induced by proinflammatory macrophages are involved in the pathological processes of intervertebral disc (IVD) degeneration (IVDD). Our previous study suggested the protective role of inhibiting heat shock protein 90 (HSP90) in IVDD, while the underlying mec...

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Detalles Bibliográficos
Autores principales:	Zhang, Shuo, Wang, Peng, Hu, Binwu, Liu, Weijian, Lv, Xiao, Chen, Songfeng, Shao, Zengwu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763810/ https://www.ncbi.nlm.nih.gov/pubmed/35059401 http://dx.doi.org/10.3389/fcell.2021.796974

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