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Mucormycosis Amid COVID-19 Crisis: Pathogenesis, Diagnosis, and Novel Treatment Strategies to Combat the Spread

The havoc unleashed by COVID-19 pandemic has paved way for secondary ominous fungal infections like Mucormycosis. It is caused by a class of opportunistic pathogens from the order Mucorales. Fatality rates due to this contagious infection are extremely high. Numerous clinical manifestations result i...

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Autores principales: Dogra, Shreya, Arora, Akanksha, Aggarwal, Aashni, Passi, Gautam, Sharma, Akanksha, Singh, Gurpal, Barnwal, Ravi P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763841/
https://www.ncbi.nlm.nih.gov/pubmed/35058909
http://dx.doi.org/10.3389/fmicb.2021.794176
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author Dogra, Shreya
Arora, Akanksha
Aggarwal, Aashni
Passi, Gautam
Sharma, Akanksha
Singh, Gurpal
Barnwal, Ravi P.
author_facet Dogra, Shreya
Arora, Akanksha
Aggarwal, Aashni
Passi, Gautam
Sharma, Akanksha
Singh, Gurpal
Barnwal, Ravi P.
author_sort Dogra, Shreya
collection PubMed
description The havoc unleashed by COVID-19 pandemic has paved way for secondary ominous fungal infections like Mucormycosis. It is caused by a class of opportunistic pathogens from the order Mucorales. Fatality rates due to this contagious infection are extremely high. Numerous clinical manifestations result in damage to multiple organs subject to the patient’s underlying condition. Lack of a proper detection method and reliable treatment has made the management of this infection troublesome. Several reports studying the behavior pattern of Mucorales inside the host by modulation of its defense mechanisms have helped in understanding the pathogenesis of this angio-invasive infection. Many recent advances in diagnosis and treatment of this fungal infection have not been much beneficial. Therefore, there is a need to foster more viable strategies. This article summarizes current and imminent approaches that could aid effective management of these secondary infections in these times of global pandemic. It is foreseen that the development of newer antifungal drugs, antimicrobial peptides, and nanotechnology-based approaches for drug delivery would help combat this infection and curb its spread.
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spelling pubmed-87638412022-01-19 Mucormycosis Amid COVID-19 Crisis: Pathogenesis, Diagnosis, and Novel Treatment Strategies to Combat the Spread Dogra, Shreya Arora, Akanksha Aggarwal, Aashni Passi, Gautam Sharma, Akanksha Singh, Gurpal Barnwal, Ravi P. Front Microbiol Microbiology The havoc unleashed by COVID-19 pandemic has paved way for secondary ominous fungal infections like Mucormycosis. It is caused by a class of opportunistic pathogens from the order Mucorales. Fatality rates due to this contagious infection are extremely high. Numerous clinical manifestations result in damage to multiple organs subject to the patient’s underlying condition. Lack of a proper detection method and reliable treatment has made the management of this infection troublesome. Several reports studying the behavior pattern of Mucorales inside the host by modulation of its defense mechanisms have helped in understanding the pathogenesis of this angio-invasive infection. Many recent advances in diagnosis and treatment of this fungal infection have not been much beneficial. Therefore, there is a need to foster more viable strategies. This article summarizes current and imminent approaches that could aid effective management of these secondary infections in these times of global pandemic. It is foreseen that the development of newer antifungal drugs, antimicrobial peptides, and nanotechnology-based approaches for drug delivery would help combat this infection and curb its spread. Frontiers Media S.A. 2022-01-04 /pmc/articles/PMC8763841/ /pubmed/35058909 http://dx.doi.org/10.3389/fmicb.2021.794176 Text en Copyright © 2022 Dogra, Arora, Aggarwal, Passi, Sharma, Singh and Barnwal. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Dogra, Shreya
Arora, Akanksha
Aggarwal, Aashni
Passi, Gautam
Sharma, Akanksha
Singh, Gurpal
Barnwal, Ravi P.
Mucormycosis Amid COVID-19 Crisis: Pathogenesis, Diagnosis, and Novel Treatment Strategies to Combat the Spread
title Mucormycosis Amid COVID-19 Crisis: Pathogenesis, Diagnosis, and Novel Treatment Strategies to Combat the Spread
title_full Mucormycosis Amid COVID-19 Crisis: Pathogenesis, Diagnosis, and Novel Treatment Strategies to Combat the Spread
title_fullStr Mucormycosis Amid COVID-19 Crisis: Pathogenesis, Diagnosis, and Novel Treatment Strategies to Combat the Spread
title_full_unstemmed Mucormycosis Amid COVID-19 Crisis: Pathogenesis, Diagnosis, and Novel Treatment Strategies to Combat the Spread
title_short Mucormycosis Amid COVID-19 Crisis: Pathogenesis, Diagnosis, and Novel Treatment Strategies to Combat the Spread
title_sort mucormycosis amid covid-19 crisis: pathogenesis, diagnosis, and novel treatment strategies to combat the spread
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763841/
https://www.ncbi.nlm.nih.gov/pubmed/35058909
http://dx.doi.org/10.3389/fmicb.2021.794176
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