Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction

We report the discovery of a facile peptide macrocyclization and stapling strategy based on a fluorine thiol displacement reaction (FTDR), which renders a class of peptide analogues with enhanced stability, affinity, cellular uptake, and inhibition of cancer cells. This approach enabled selective mo...

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Detalles Bibliográficos
Autores principales: Islam, Md Shafiqul, Junod, Samuel L., Zhang, Si, Buuh, Zakey Yusuf, Guan, Yifu, Zhao, Mi, Kaneria, Kishan H., Kafley, Parmila, Cohen, Carson, Maloney, Robert, Lyu, Zhigang, Voelz, Vincent A., Yang, Weidong, Wang, Rongsheng E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763920/
https://www.ncbi.nlm.nih.gov/pubmed/35039490
http://dx.doi.org/10.1038/s41467-022-27995-5

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