In vitro and clinical investigations to determine the drug-drug interaction potential of entrectinib, a small molecule inhibitor of neurotrophic tyrosine receptor kinase (NTRK)

Background Entrectinib is a CNS-active, potent inhibitor of tyrosine receptor kinases A/B/C, ROS1 and anaplastic lymphoma kinase approved for use in patients with solid tumors. We describe the in vitro and clinical studies investigating potential entrectinib drug-drug interactions. Methods In vitro...

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Detalles Bibliográficos
Autores principales: Meneses-Lorente, Georgina, Fowler, Stephen, Guerini, Elena, Kowalski, Karey, Chow-Maneval, Edna, Yu, Li, Mercier, Francois, Ullah, Mohammed, Umehara, Kenichi, Brink, Andreas, Buchheit, Vincent, Zwanziger, Elke, Phipps, Alex, Djebli, Nassim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Phase I Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763936/
https://www.ncbi.nlm.nih.gov/pubmed/34417912
http://dx.doi.org/10.1007/s10637-021-01156-9

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