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Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain

Most public cord blood banking programs are currently facing financial difficulties due to a progressive decline in the number of cord blood transplants performed worldwide and to a high discard rate of the donated units caused by progressively increasing thresholds of the stem cell dose required to...

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Autores principales: Rebulla, Paolo, Querol, Sergio, Pupella, Simonetta, Prati, Daniele, Delgadillo, Joaquin, De Angelis, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763965/
https://www.ncbi.nlm.nih.gov/pubmed/35059402
http://dx.doi.org/10.3389/fcell.2021.812038
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author Rebulla, Paolo
Querol, Sergio
Pupella, Simonetta
Prati, Daniele
Delgadillo, Joaquin
De Angelis, Vincenzo
author_facet Rebulla, Paolo
Querol, Sergio
Pupella, Simonetta
Prati, Daniele
Delgadillo, Joaquin
De Angelis, Vincenzo
author_sort Rebulla, Paolo
collection PubMed
description Most public cord blood banking programs are currently facing financial difficulties due to a progressive decline in the number of cord blood transplants performed worldwide and to a high discard rate of the donated units caused by progressively increasing thresholds of the stem cell dose required to perform safe and effective hemopoietic cord blood transplants. Recycling a proportion of unused cord blood units to prepare novel cord blood components obtained with minimal manipulation (platelets, plasma, red blood cells) and to develop more technologically complex products regulated in the US as Cellular and Gene Therapy Products and in Europe as Advanced Therapy Medicinal Products [e.g. virus-specific T cells (VST), natural killer (NK) cells, induced pluripotent stem cells (iPSCs) is a promising strategy to increase the therapeutic value and reduce the financial deficits of public cord blood banking. Based on encouraging preliminary evidences reported in the literature, additional laboratory studies, large multicenter clinical trials and international regulatory harmonization are necessary to achieve these important goals. This article describes organizational, methodological and regulatory advancements developed in Italy and Spain to promote the clinical use of cord blood platelets, plasma and red blood cells.
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spelling pubmed-87639652022-01-19 Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain Rebulla, Paolo Querol, Sergio Pupella, Simonetta Prati, Daniele Delgadillo, Joaquin De Angelis, Vincenzo Front Cell Dev Biol Cell and Developmental Biology Most public cord blood banking programs are currently facing financial difficulties due to a progressive decline in the number of cord blood transplants performed worldwide and to a high discard rate of the donated units caused by progressively increasing thresholds of the stem cell dose required to perform safe and effective hemopoietic cord blood transplants. Recycling a proportion of unused cord blood units to prepare novel cord blood components obtained with minimal manipulation (platelets, plasma, red blood cells) and to develop more technologically complex products regulated in the US as Cellular and Gene Therapy Products and in Europe as Advanced Therapy Medicinal Products [e.g. virus-specific T cells (VST), natural killer (NK) cells, induced pluripotent stem cells (iPSCs) is a promising strategy to increase the therapeutic value and reduce the financial deficits of public cord blood banking. Based on encouraging preliminary evidences reported in the literature, additional laboratory studies, large multicenter clinical trials and international regulatory harmonization are necessary to achieve these important goals. This article describes organizational, methodological and regulatory advancements developed in Italy and Spain to promote the clinical use of cord blood platelets, plasma and red blood cells. Frontiers Media S.A. 2022-01-04 /pmc/articles/PMC8763965/ /pubmed/35059402 http://dx.doi.org/10.3389/fcell.2021.812038 Text en Copyright © 2022 Rebulla, Querol, Pupella, Prati, Delgadillo and De Angelis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Rebulla, Paolo
Querol, Sergio
Pupella, Simonetta
Prati, Daniele
Delgadillo, Joaquin
De Angelis, Vincenzo
Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain
title Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain
title_full Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain
title_fullStr Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain
title_full_unstemmed Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain
title_short Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain
title_sort recycling apparent waste into biologicals: the case of umbilical cord blood in italy and spain
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763965/
https://www.ncbi.nlm.nih.gov/pubmed/35059402
http://dx.doi.org/10.3389/fcell.2021.812038
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