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The Wnt Signaling Pathway in Diabetic Nephropathy
Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease. DN can lead to hypertension, edema, and proteinuria. In some cases, DN can even progress to kidney failure, a life-threa...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763969/ https://www.ncbi.nlm.nih.gov/pubmed/35059392 http://dx.doi.org/10.3389/fcell.2021.701547 |
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author | Wang, Haiying Zhang, Ran Wu, Xinjie Chen, Yafen Ji, Wei Wang, Jingsuo Zhang, Yawen Xia, Yong Tang, Yiqun Yuan, Jinxiang |
author_facet | Wang, Haiying Zhang, Ran Wu, Xinjie Chen, Yafen Ji, Wei Wang, Jingsuo Zhang, Yawen Xia, Yong Tang, Yiqun Yuan, Jinxiang |
author_sort | Wang, Haiying |
collection | PubMed |
description | Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease. DN can lead to hypertension, edema, and proteinuria. In some cases, DN can even progress to kidney failure, a life-threatening condition. The precise etiology and pathogenesis of DN remain unknown, although multiple factors are believed to be involved. The main pathological manifestations of DN include mesangial expansion, thickening of the glomerular basement membrane, and podocyte injury. Eventually, these pathological manifestations will lead to glomerulosclerosis, thus affecting renal function. There is an urgent need to develop new strategies for the prevention and treatment of DN. Existing evidence shows that the Wnt signaling cascade plays a key role in regulating the development of DN. Previous studies focused on the role of the Wnt canonical signaling pathway in DN. Subsequently, accumulated evidence on the mechanism of the Wnt non-canonical signaling indicated that Wnt/Ca(2+) and Wnt/PCP also have essential roles in the progression of DN. In this review, we summarize the specific mechanisms of Wnt signaling in the occurrence and development of DN in podocyte injury, mesangial cell injury, and renal fibrosis. Also, to elucidate the significance of the Wnt canonical pathway in the process of DN, we uncovered evidence supporting that both Wnt/PCP and Wnt/Ca(2+) signaling are critical for DN development. |
format | Online Article Text |
id | pubmed-8763969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87639692022-01-19 The Wnt Signaling Pathway in Diabetic Nephropathy Wang, Haiying Zhang, Ran Wu, Xinjie Chen, Yafen Ji, Wei Wang, Jingsuo Zhang, Yawen Xia, Yong Tang, Yiqun Yuan, Jinxiang Front Cell Dev Biol Cell and Developmental Biology Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease. DN can lead to hypertension, edema, and proteinuria. In some cases, DN can even progress to kidney failure, a life-threatening condition. The precise etiology and pathogenesis of DN remain unknown, although multiple factors are believed to be involved. The main pathological manifestations of DN include mesangial expansion, thickening of the glomerular basement membrane, and podocyte injury. Eventually, these pathological manifestations will lead to glomerulosclerosis, thus affecting renal function. There is an urgent need to develop new strategies for the prevention and treatment of DN. Existing evidence shows that the Wnt signaling cascade plays a key role in regulating the development of DN. Previous studies focused on the role of the Wnt canonical signaling pathway in DN. Subsequently, accumulated evidence on the mechanism of the Wnt non-canonical signaling indicated that Wnt/Ca(2+) and Wnt/PCP also have essential roles in the progression of DN. In this review, we summarize the specific mechanisms of Wnt signaling in the occurrence and development of DN in podocyte injury, mesangial cell injury, and renal fibrosis. Also, to elucidate the significance of the Wnt canonical pathway in the process of DN, we uncovered evidence supporting that both Wnt/PCP and Wnt/Ca(2+) signaling are critical for DN development. Frontiers Media S.A. 2022-01-04 /pmc/articles/PMC8763969/ /pubmed/35059392 http://dx.doi.org/10.3389/fcell.2021.701547 Text en Copyright © 2022 Wang, Zhang, Wu, Chen, Ji, Wang, Zhang, Xia, Tang and Yuan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Wang, Haiying Zhang, Ran Wu, Xinjie Chen, Yafen Ji, Wei Wang, Jingsuo Zhang, Yawen Xia, Yong Tang, Yiqun Yuan, Jinxiang The Wnt Signaling Pathway in Diabetic Nephropathy |
title | The Wnt Signaling Pathway in Diabetic Nephropathy |
title_full | The Wnt Signaling Pathway in Diabetic Nephropathy |
title_fullStr | The Wnt Signaling Pathway in Diabetic Nephropathy |
title_full_unstemmed | The Wnt Signaling Pathway in Diabetic Nephropathy |
title_short | The Wnt Signaling Pathway in Diabetic Nephropathy |
title_sort | wnt signaling pathway in diabetic nephropathy |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763969/ https://www.ncbi.nlm.nih.gov/pubmed/35059392 http://dx.doi.org/10.3389/fcell.2021.701547 |
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