Cargando…

The Wnt Signaling Pathway in Diabetic Nephropathy

Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease. DN can lead to hypertension, edema, and proteinuria. In some cases, DN can even progress to kidney failure, a life-threa...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Haiying, Zhang, Ran, Wu, Xinjie, Chen, Yafen, Ji, Wei, Wang, Jingsuo, Zhang, Yawen, Xia, Yong, Tang, Yiqun, Yuan, Jinxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763969/
https://www.ncbi.nlm.nih.gov/pubmed/35059392
http://dx.doi.org/10.3389/fcell.2021.701547
_version_ 1784634066457329664
author Wang, Haiying
Zhang, Ran
Wu, Xinjie
Chen, Yafen
Ji, Wei
Wang, Jingsuo
Zhang, Yawen
Xia, Yong
Tang, Yiqun
Yuan, Jinxiang
author_facet Wang, Haiying
Zhang, Ran
Wu, Xinjie
Chen, Yafen
Ji, Wei
Wang, Jingsuo
Zhang, Yawen
Xia, Yong
Tang, Yiqun
Yuan, Jinxiang
author_sort Wang, Haiying
collection PubMed
description Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease. DN can lead to hypertension, edema, and proteinuria. In some cases, DN can even progress to kidney failure, a life-threatening condition. The precise etiology and pathogenesis of DN remain unknown, although multiple factors are believed to be involved. The main pathological manifestations of DN include mesangial expansion, thickening of the glomerular basement membrane, and podocyte injury. Eventually, these pathological manifestations will lead to glomerulosclerosis, thus affecting renal function. There is an urgent need to develop new strategies for the prevention and treatment of DN. Existing evidence shows that the Wnt signaling cascade plays a key role in regulating the development of DN. Previous studies focused on the role of the Wnt canonical signaling pathway in DN. Subsequently, accumulated evidence on the mechanism of the Wnt non-canonical signaling indicated that Wnt/Ca(2+) and Wnt/PCP also have essential roles in the progression of DN. In this review, we summarize the specific mechanisms of Wnt signaling in the occurrence and development of DN in podocyte injury, mesangial cell injury, and renal fibrosis. Also, to elucidate the significance of the Wnt canonical pathway in the process of DN, we uncovered evidence supporting that both Wnt/PCP and Wnt/Ca(2+) signaling are critical for DN development.
format Online
Article
Text
id pubmed-8763969
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87639692022-01-19 The Wnt Signaling Pathway in Diabetic Nephropathy Wang, Haiying Zhang, Ran Wu, Xinjie Chen, Yafen Ji, Wei Wang, Jingsuo Zhang, Yawen Xia, Yong Tang, Yiqun Yuan, Jinxiang Front Cell Dev Biol Cell and Developmental Biology Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease. DN can lead to hypertension, edema, and proteinuria. In some cases, DN can even progress to kidney failure, a life-threatening condition. The precise etiology and pathogenesis of DN remain unknown, although multiple factors are believed to be involved. The main pathological manifestations of DN include mesangial expansion, thickening of the glomerular basement membrane, and podocyte injury. Eventually, these pathological manifestations will lead to glomerulosclerosis, thus affecting renal function. There is an urgent need to develop new strategies for the prevention and treatment of DN. Existing evidence shows that the Wnt signaling cascade plays a key role in regulating the development of DN. Previous studies focused on the role of the Wnt canonical signaling pathway in DN. Subsequently, accumulated evidence on the mechanism of the Wnt non-canonical signaling indicated that Wnt/Ca(2+) and Wnt/PCP also have essential roles in the progression of DN. In this review, we summarize the specific mechanisms of Wnt signaling in the occurrence and development of DN in podocyte injury, mesangial cell injury, and renal fibrosis. Also, to elucidate the significance of the Wnt canonical pathway in the process of DN, we uncovered evidence supporting that both Wnt/PCP and Wnt/Ca(2+) signaling are critical for DN development. Frontiers Media S.A. 2022-01-04 /pmc/articles/PMC8763969/ /pubmed/35059392 http://dx.doi.org/10.3389/fcell.2021.701547 Text en Copyright © 2022 Wang, Zhang, Wu, Chen, Ji, Wang, Zhang, Xia, Tang and Yuan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wang, Haiying
Zhang, Ran
Wu, Xinjie
Chen, Yafen
Ji, Wei
Wang, Jingsuo
Zhang, Yawen
Xia, Yong
Tang, Yiqun
Yuan, Jinxiang
The Wnt Signaling Pathway in Diabetic Nephropathy
title The Wnt Signaling Pathway in Diabetic Nephropathy
title_full The Wnt Signaling Pathway in Diabetic Nephropathy
title_fullStr The Wnt Signaling Pathway in Diabetic Nephropathy
title_full_unstemmed The Wnt Signaling Pathway in Diabetic Nephropathy
title_short The Wnt Signaling Pathway in Diabetic Nephropathy
title_sort wnt signaling pathway in diabetic nephropathy
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763969/
https://www.ncbi.nlm.nih.gov/pubmed/35059392
http://dx.doi.org/10.3389/fcell.2021.701547
work_keys_str_mv AT wanghaiying thewntsignalingpathwayindiabeticnephropathy
AT zhangran thewntsignalingpathwayindiabeticnephropathy
AT wuxinjie thewntsignalingpathwayindiabeticnephropathy
AT chenyafen thewntsignalingpathwayindiabeticnephropathy
AT jiwei thewntsignalingpathwayindiabeticnephropathy
AT wangjingsuo thewntsignalingpathwayindiabeticnephropathy
AT zhangyawen thewntsignalingpathwayindiabeticnephropathy
AT xiayong thewntsignalingpathwayindiabeticnephropathy
AT tangyiqun thewntsignalingpathwayindiabeticnephropathy
AT yuanjinxiang thewntsignalingpathwayindiabeticnephropathy
AT wanghaiying wntsignalingpathwayindiabeticnephropathy
AT zhangran wntsignalingpathwayindiabeticnephropathy
AT wuxinjie wntsignalingpathwayindiabeticnephropathy
AT chenyafen wntsignalingpathwayindiabeticnephropathy
AT jiwei wntsignalingpathwayindiabeticnephropathy
AT wangjingsuo wntsignalingpathwayindiabeticnephropathy
AT zhangyawen wntsignalingpathwayindiabeticnephropathy
AT xiayong wntsignalingpathwayindiabeticnephropathy
AT tangyiqun wntsignalingpathwayindiabeticnephropathy
AT yuanjinxiang wntsignalingpathwayindiabeticnephropathy