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Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)

The study aimed to discriminate renal allografts with impaired function by measuring cortical renal blood flow (cRBF) using magnetic resonance imaging arterial spin labelling (ASL-MRI) in paediatric and young adult patients. We included 18 subjects and performed ASL-MRI on 1.5 T MRI to calculate cRB...

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Autores principales: Radovic, Tijana, Jankovic, Milica M., Stevic, Ruza, Spasojevic, Brankica, Cvetkovic, Mirjana, Pavicevic, Polina, Gojkovic, Ivana, Kostic, Mirjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764097/
https://www.ncbi.nlm.nih.gov/pubmed/35039571
http://dx.doi.org/10.1038/s41598-022-04794-y
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author Radovic, Tijana
Jankovic, Milica M.
Stevic, Ruza
Spasojevic, Brankica
Cvetkovic, Mirjana
Pavicevic, Polina
Gojkovic, Ivana
Kostic, Mirjana
author_facet Radovic, Tijana
Jankovic, Milica M.
Stevic, Ruza
Spasojevic, Brankica
Cvetkovic, Mirjana
Pavicevic, Polina
Gojkovic, Ivana
Kostic, Mirjana
author_sort Radovic, Tijana
collection PubMed
description The study aimed to discriminate renal allografts with impaired function by measuring cortical renal blood flow (cRBF) using magnetic resonance imaging arterial spin labelling (ASL-MRI) in paediatric and young adult patients. We included 18 subjects and performed ASL-MRI on 1.5 T MRI to calculate cRBF on parameter maps. cRBF was correlated to calculated glomerular filtration rate (GFR) and compared between patient groups with good (GFR ≥ 60 mL/min/1.73 m(2)) and impaired allograft function (GFR < 60 mL/min/1.73 m(2)). Mean cRBF in patients with good allograft function was significantly higher than in patients with impaired allograft function (219.89 ± 57.24 mL/min/100 g vs. 146.22 ± 41.84 mL/min/100 g, p < 0.008), showing a highly significant correlation with GFR in all subjects (r = 0.75, p < 0.0001). Also, the diffusion-weighted imaging (DWI-MRI) apparent diffusion coefficient (ADC) and Doppler measurements of peak-systolic and end-diastolic velocities and the resistive index (PS, ED, RI) were performed and both methods showed no significant difference between groups. ADC implied no correlation with GFR (r = 0.198, p = 0.464), while PS indicated moderate correlation to GFR (r = 0.48, p < 0.05), and PS and ED moderate correlation to cRBF (r = 0.58, p < 0.05, r = 0.56, p < 0.05, respectively). Cortical perfusion as non-invasively measured by ASL-MRI differs between patients with good and impaired allograft function and correlates significantly with its function.
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spelling pubmed-87640972022-01-18 Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI) Radovic, Tijana Jankovic, Milica M. Stevic, Ruza Spasojevic, Brankica Cvetkovic, Mirjana Pavicevic, Polina Gojkovic, Ivana Kostic, Mirjana Sci Rep Article The study aimed to discriminate renal allografts with impaired function by measuring cortical renal blood flow (cRBF) using magnetic resonance imaging arterial spin labelling (ASL-MRI) in paediatric and young adult patients. We included 18 subjects and performed ASL-MRI on 1.5 T MRI to calculate cRBF on parameter maps. cRBF was correlated to calculated glomerular filtration rate (GFR) and compared between patient groups with good (GFR ≥ 60 mL/min/1.73 m(2)) and impaired allograft function (GFR < 60 mL/min/1.73 m(2)). Mean cRBF in patients with good allograft function was significantly higher than in patients with impaired allograft function (219.89 ± 57.24 mL/min/100 g vs. 146.22 ± 41.84 mL/min/100 g, p < 0.008), showing a highly significant correlation with GFR in all subjects (r = 0.75, p < 0.0001). Also, the diffusion-weighted imaging (DWI-MRI) apparent diffusion coefficient (ADC) and Doppler measurements of peak-systolic and end-diastolic velocities and the resistive index (PS, ED, RI) were performed and both methods showed no significant difference between groups. ADC implied no correlation with GFR (r = 0.198, p = 0.464), while PS indicated moderate correlation to GFR (r = 0.48, p < 0.05), and PS and ED moderate correlation to cRBF (r = 0.58, p < 0.05, r = 0.56, p < 0.05, respectively). Cortical perfusion as non-invasively measured by ASL-MRI differs between patients with good and impaired allograft function and correlates significantly with its function. Nature Publishing Group UK 2022-01-17 /pmc/articles/PMC8764097/ /pubmed/35039571 http://dx.doi.org/10.1038/s41598-022-04794-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Radovic, Tijana
Jankovic, Milica M.
Stevic, Ruza
Spasojevic, Brankica
Cvetkovic, Mirjana
Pavicevic, Polina
Gojkovic, Ivana
Kostic, Mirjana
Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)
title Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)
title_full Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)
title_fullStr Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)
title_full_unstemmed Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)
title_short Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)
title_sort detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling mri (asl-mri)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764097/
https://www.ncbi.nlm.nih.gov/pubmed/35039571
http://dx.doi.org/10.1038/s41598-022-04794-y
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