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Inhibition of Clostridioides difficile Toxins TcdA and TcdB by Ambroxol

Clostridioides (C.) difficile produces the exotoxins TcdA and TcdB, which are the predominant virulence factors causing C. difficile associated disease (CDAD). TcdA and TcdB bind to target cells and are internalized via receptor-mediated endocytosis. Translocation of the toxins’ enzyme subunits from...

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Detalles Bibliográficos
Autores principales:	Heber, Sebastian, Barthold, Lara, Baier, Jan, Papatheodorou, Panagiotis, Fois, Giorgio, Frick, Manfred, Barth, Holger, Fischer, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764291/ https://www.ncbi.nlm.nih.gov/pubmed/35058787 http://dx.doi.org/10.3389/fphar.2021.809595

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