Cargando…

Case Report: A Case of COVID Vaccine-Induced Thrombotic Thrombocytopenia Manifested as Pulmonary Embolism and Hemorrhagia. A First Reported Case From Slovakia

COVID-19 vaccine-induced thrombotic thrombocytopenia (VITT) is a rare complication of adenoviral vector (ChAdOx1 nCoV-19) vaccine administration. It is presented as thrombocytopenia and thrombotic manifestations in various sites, especially in cerebral veins. Pulmonary emboli have been reported rare...

Descripción completa

Detalles Bibliográficos
Autores principales: Ihnatko, Martin, Truchla, Ivana, Ihnatková, L'udmila, Prohászka, Zoltán, Lazúrová, Ivica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764362/
https://www.ncbi.nlm.nih.gov/pubmed/35059416
http://dx.doi.org/10.3389/fmed.2021.789972
_version_ 1784634146956509184
author Ihnatko, Martin
Truchla, Ivana
Ihnatková, L'udmila
Prohászka, Zoltán
Lazúrová, Ivica
author_facet Ihnatko, Martin
Truchla, Ivana
Ihnatková, L'udmila
Prohászka, Zoltán
Lazúrová, Ivica
author_sort Ihnatko, Martin
collection PubMed
description COVID-19 vaccine-induced thrombotic thrombocytopenia (VITT) is a rare complication of adenoviral vector (ChAdOx1 nCoV-19) vaccine administration. It is presented as thrombocytopenia and thrombotic manifestations in various sites, especially in cerebral veins. Pulmonary emboli have been reported rarely. We present a case of a young male patient who developed severe thrombocytopenia and pulmonary embolism 12 days after the first dose of the vaccine. Severe thrombocytopenia, skin hematomas, and segmental pulmonary emboli were detected. Anti-platelet factor 4 (aPF-4) antibody was highly positive supporting the diagnosis of VITT. Prompt treatment with fondaparinux, intravenous immunoglobulin, and prednisone led to a marked improvement of clinical condition and thrombocytes count. We report the first known case of VITT in Slovakia.
format Online
Article
Text
id pubmed-8764362
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87643622022-01-19 Case Report: A Case of COVID Vaccine-Induced Thrombotic Thrombocytopenia Manifested as Pulmonary Embolism and Hemorrhagia. A First Reported Case From Slovakia Ihnatko, Martin Truchla, Ivana Ihnatková, L'udmila Prohászka, Zoltán Lazúrová, Ivica Front Med (Lausanne) Medicine COVID-19 vaccine-induced thrombotic thrombocytopenia (VITT) is a rare complication of adenoviral vector (ChAdOx1 nCoV-19) vaccine administration. It is presented as thrombocytopenia and thrombotic manifestations in various sites, especially in cerebral veins. Pulmonary emboli have been reported rarely. We present a case of a young male patient who developed severe thrombocytopenia and pulmonary embolism 12 days after the first dose of the vaccine. Severe thrombocytopenia, skin hematomas, and segmental pulmonary emboli were detected. Anti-platelet factor 4 (aPF-4) antibody was highly positive supporting the diagnosis of VITT. Prompt treatment with fondaparinux, intravenous immunoglobulin, and prednisone led to a marked improvement of clinical condition and thrombocytes count. We report the first known case of VITT in Slovakia. Frontiers Media S.A. 2022-01-04 /pmc/articles/PMC8764362/ /pubmed/35059416 http://dx.doi.org/10.3389/fmed.2021.789972 Text en Copyright © 2022 Ihnatko, Truchla, Ihnatková, Prohászka and Lazúrová. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Ihnatko, Martin
Truchla, Ivana
Ihnatková, L'udmila
Prohászka, Zoltán
Lazúrová, Ivica
Case Report: A Case of COVID Vaccine-Induced Thrombotic Thrombocytopenia Manifested as Pulmonary Embolism and Hemorrhagia. A First Reported Case From Slovakia
title Case Report: A Case of COVID Vaccine-Induced Thrombotic Thrombocytopenia Manifested as Pulmonary Embolism and Hemorrhagia. A First Reported Case From Slovakia
title_full Case Report: A Case of COVID Vaccine-Induced Thrombotic Thrombocytopenia Manifested as Pulmonary Embolism and Hemorrhagia. A First Reported Case From Slovakia
title_fullStr Case Report: A Case of COVID Vaccine-Induced Thrombotic Thrombocytopenia Manifested as Pulmonary Embolism and Hemorrhagia. A First Reported Case From Slovakia
title_full_unstemmed Case Report: A Case of COVID Vaccine-Induced Thrombotic Thrombocytopenia Manifested as Pulmonary Embolism and Hemorrhagia. A First Reported Case From Slovakia
title_short Case Report: A Case of COVID Vaccine-Induced Thrombotic Thrombocytopenia Manifested as Pulmonary Embolism and Hemorrhagia. A First Reported Case From Slovakia
title_sort case report: a case of covid vaccine-induced thrombotic thrombocytopenia manifested as pulmonary embolism and hemorrhagia. a first reported case from slovakia
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764362/
https://www.ncbi.nlm.nih.gov/pubmed/35059416
http://dx.doi.org/10.3389/fmed.2021.789972
work_keys_str_mv AT ihnatkomartin casereportacaseofcovidvaccineinducedthromboticthrombocytopeniamanifestedaspulmonaryembolismandhemorrhagiaafirstreportedcasefromslovakia
AT truchlaivana casereportacaseofcovidvaccineinducedthromboticthrombocytopeniamanifestedaspulmonaryembolismandhemorrhagiaafirstreportedcasefromslovakia
AT ihnatkovaludmila casereportacaseofcovidvaccineinducedthromboticthrombocytopeniamanifestedaspulmonaryembolismandhemorrhagiaafirstreportedcasefromslovakia
AT prohaszkazoltan casereportacaseofcovidvaccineinducedthromboticthrombocytopeniamanifestedaspulmonaryembolismandhemorrhagiaafirstreportedcasefromslovakia
AT lazurovaivica casereportacaseofcovidvaccineinducedthromboticthrombocytopeniamanifestedaspulmonaryembolismandhemorrhagiaafirstreportedcasefromslovakia