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Novel Targets and Interventions for Cognitive Complications of Diabetes
Diabetes and cognitive dysfunction, ranging from mild cognitive impairment to dementia, often coexist in individuals over 65 years of age. Vascular contributions to cognitive impairment/dementia (VCID) are the second leading cause of dementias under the umbrella of Alzheimer’s disease and related de...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764363/ https://www.ncbi.nlm.nih.gov/pubmed/35058808 http://dx.doi.org/10.3389/fphys.2021.815758 |
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author | Wolf, Victoria Abdul, Yasir Ergul, Adviye |
author_facet | Wolf, Victoria Abdul, Yasir Ergul, Adviye |
author_sort | Wolf, Victoria |
collection | PubMed |
description | Diabetes and cognitive dysfunction, ranging from mild cognitive impairment to dementia, often coexist in individuals over 65 years of age. Vascular contributions to cognitive impairment/dementia (VCID) are the second leading cause of dementias under the umbrella of Alzheimer’s disease and related dementias (ADRD). Over half of dementia patients have VCID either as a single pathology or a mixed dementia with AD. While the prevalence of type 2 diabetes in individuals with dementia can be as high as 39% and diabetes increases the risk of cerebrovascular disease and stroke, VCID remains to be one of the less understood and less studied complications of diabetes. We have identified cerebrovascular dysfunction and compromised endothelial integrity leading to decreased cerebral blood flow and iron deposition into the brain, respectively, as targets for intervention for the prevention of VCID in diabetes. This review will focus on targeted therapies that improve endothelial function or remove iron without systemic effects, such as agents delivered intranasally, that may result in actionable and disease-modifying novel treatments in the high-risk diabetic population. |
format | Online Article Text |
id | pubmed-8764363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87643632022-01-19 Novel Targets and Interventions for Cognitive Complications of Diabetes Wolf, Victoria Abdul, Yasir Ergul, Adviye Front Physiol Physiology Diabetes and cognitive dysfunction, ranging from mild cognitive impairment to dementia, often coexist in individuals over 65 years of age. Vascular contributions to cognitive impairment/dementia (VCID) are the second leading cause of dementias under the umbrella of Alzheimer’s disease and related dementias (ADRD). Over half of dementia patients have VCID either as a single pathology or a mixed dementia with AD. While the prevalence of type 2 diabetes in individuals with dementia can be as high as 39% and diabetes increases the risk of cerebrovascular disease and stroke, VCID remains to be one of the less understood and less studied complications of diabetes. We have identified cerebrovascular dysfunction and compromised endothelial integrity leading to decreased cerebral blood flow and iron deposition into the brain, respectively, as targets for intervention for the prevention of VCID in diabetes. This review will focus on targeted therapies that improve endothelial function or remove iron without systemic effects, such as agents delivered intranasally, that may result in actionable and disease-modifying novel treatments in the high-risk diabetic population. Frontiers Media S.A. 2022-01-04 /pmc/articles/PMC8764363/ /pubmed/35058808 http://dx.doi.org/10.3389/fphys.2021.815758 Text en Copyright © 2022 Wolf, Abdul and Ergul. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Wolf, Victoria Abdul, Yasir Ergul, Adviye Novel Targets and Interventions for Cognitive Complications of Diabetes |
title | Novel Targets and Interventions for Cognitive Complications of Diabetes |
title_full | Novel Targets and Interventions for Cognitive Complications of Diabetes |
title_fullStr | Novel Targets and Interventions for Cognitive Complications of Diabetes |
title_full_unstemmed | Novel Targets and Interventions for Cognitive Complications of Diabetes |
title_short | Novel Targets and Interventions for Cognitive Complications of Diabetes |
title_sort | novel targets and interventions for cognitive complications of diabetes |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764363/ https://www.ncbi.nlm.nih.gov/pubmed/35058808 http://dx.doi.org/10.3389/fphys.2021.815758 |
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