Cargando…
Structural connectome differences in pediatric mild traumatic brain and orthopedic injury
Sophisticated network‐based approaches such as structural connectomics may help to detect a biomarker of mild traumatic brain injury (mTBI) in children. This study compared the structural connectome of children with mTBI or mild orthopedic injury (OI) to that of typically developing (TD) children. C...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764485/ https://www.ncbi.nlm.nih.gov/pubmed/34748258 http://dx.doi.org/10.1002/hbm.25705 |
_version_ | 1784634177234141184 |
---|---|
author | Ware, Ashley L. Yeates, Keith Owen Geeraert, Bryce Long, Xiangyu Beauchamp, Miriam H. Craig, William Doan, Quynh Freedman, Stephen B. Goodyear, Bradley G. Zemek, Roger Lebel, Catherine |
author_facet | Ware, Ashley L. Yeates, Keith Owen Geeraert, Bryce Long, Xiangyu Beauchamp, Miriam H. Craig, William Doan, Quynh Freedman, Stephen B. Goodyear, Bradley G. Zemek, Roger Lebel, Catherine |
author_sort | Ware, Ashley L. |
collection | PubMed |
description | Sophisticated network‐based approaches such as structural connectomics may help to detect a biomarker of mild traumatic brain injury (mTBI) in children. This study compared the structural connectome of children with mTBI or mild orthopedic injury (OI) to that of typically developing (TD) children. Children aged 8–16.99 years with mTBI (n = 83) or OI (n = 37) were recruited from the emergency department and completed 3T diffusion MRI 2–20 days postinjury. TD children (n = 39) were recruited from the community and completed diffusion MRI. Graph theory metrics were calculated for the binarized average fractional anisotropy among 90 regions. Multivariable linear regression and linear mixed effects models were used to compare groups, with covariates age, hemisphere, and sex, correcting for multiple comparisons. The two injury groups did not differ on graph theory metrics, but both differed from TD children in global metrics (local network efficiency: TD > OI, mTBI, d = 0.49; clustering coefficient: TD < OI, mTBI, d = 0.49) and regional metrics for the fusiform gyrus (lower degree centrality and nodal efficiency: TD > OI, mTBI, d = 0.80 to 0.96; characteristic path length: TD < OI, mTBI, d = −0.75 to −0.90) and in the superior and middle orbital frontal gyrus, paracentral lobule, insula, and thalamus (clustering coefficient: TD > OI, mTBI, d = 0.66 to 0.68). Both mTBI and OI demonstrated reduced global and regional network efficiency and segregation as compared to TD children. Findings suggest a general effect of childhood injury that could reflect pre‐ and postinjury factors that can alter brain structure. An OI group provides a more conservative comparison group than TD children for structural neuroimaging research in pediatric mTBI. |
format | Online Article Text |
id | pubmed-8764485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87644852022-01-21 Structural connectome differences in pediatric mild traumatic brain and orthopedic injury Ware, Ashley L. Yeates, Keith Owen Geeraert, Bryce Long, Xiangyu Beauchamp, Miriam H. Craig, William Doan, Quynh Freedman, Stephen B. Goodyear, Bradley G. Zemek, Roger Lebel, Catherine Hum Brain Mapp Research Articles Sophisticated network‐based approaches such as structural connectomics may help to detect a biomarker of mild traumatic brain injury (mTBI) in children. This study compared the structural connectome of children with mTBI or mild orthopedic injury (OI) to that of typically developing (TD) children. Children aged 8–16.99 years with mTBI (n = 83) or OI (n = 37) were recruited from the emergency department and completed 3T diffusion MRI 2–20 days postinjury. TD children (n = 39) were recruited from the community and completed diffusion MRI. Graph theory metrics were calculated for the binarized average fractional anisotropy among 90 regions. Multivariable linear regression and linear mixed effects models were used to compare groups, with covariates age, hemisphere, and sex, correcting for multiple comparisons. The two injury groups did not differ on graph theory metrics, but both differed from TD children in global metrics (local network efficiency: TD > OI, mTBI, d = 0.49; clustering coefficient: TD < OI, mTBI, d = 0.49) and regional metrics for the fusiform gyrus (lower degree centrality and nodal efficiency: TD > OI, mTBI, d = 0.80 to 0.96; characteristic path length: TD < OI, mTBI, d = −0.75 to −0.90) and in the superior and middle orbital frontal gyrus, paracentral lobule, insula, and thalamus (clustering coefficient: TD > OI, mTBI, d = 0.66 to 0.68). Both mTBI and OI demonstrated reduced global and regional network efficiency and segregation as compared to TD children. Findings suggest a general effect of childhood injury that could reflect pre‐ and postinjury factors that can alter brain structure. An OI group provides a more conservative comparison group than TD children for structural neuroimaging research in pediatric mTBI. John Wiley & Sons, Inc. 2021-11-08 /pmc/articles/PMC8764485/ /pubmed/34748258 http://dx.doi.org/10.1002/hbm.25705 Text en © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Ware, Ashley L. Yeates, Keith Owen Geeraert, Bryce Long, Xiangyu Beauchamp, Miriam H. Craig, William Doan, Quynh Freedman, Stephen B. Goodyear, Bradley G. Zemek, Roger Lebel, Catherine Structural connectome differences in pediatric mild traumatic brain and orthopedic injury |
title | Structural connectome differences in pediatric mild traumatic brain and orthopedic injury |
title_full | Structural connectome differences in pediatric mild traumatic brain and orthopedic injury |
title_fullStr | Structural connectome differences in pediatric mild traumatic brain and orthopedic injury |
title_full_unstemmed | Structural connectome differences in pediatric mild traumatic brain and orthopedic injury |
title_short | Structural connectome differences in pediatric mild traumatic brain and orthopedic injury |
title_sort | structural connectome differences in pediatric mild traumatic brain and orthopedic injury |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764485/ https://www.ncbi.nlm.nih.gov/pubmed/34748258 http://dx.doi.org/10.1002/hbm.25705 |
work_keys_str_mv | AT wareashleyl structuralconnectomedifferencesinpediatricmildtraumaticbrainandorthopedicinjury AT yeateskeithowen structuralconnectomedifferencesinpediatricmildtraumaticbrainandorthopedicinjury AT geeraertbryce structuralconnectomedifferencesinpediatricmildtraumaticbrainandorthopedicinjury AT longxiangyu structuralconnectomedifferencesinpediatricmildtraumaticbrainandorthopedicinjury AT beauchampmiriamh structuralconnectomedifferencesinpediatricmildtraumaticbrainandorthopedicinjury AT craigwilliam structuralconnectomedifferencesinpediatricmildtraumaticbrainandorthopedicinjury AT doanquynh structuralconnectomedifferencesinpediatricmildtraumaticbrainandorthopedicinjury AT freedmanstephenb structuralconnectomedifferencesinpediatricmildtraumaticbrainandorthopedicinjury AT goodyearbradleyg structuralconnectomedifferencesinpediatricmildtraumaticbrainandorthopedicinjury AT zemekroger structuralconnectomedifferencesinpediatricmildtraumaticbrainandorthopedicinjury AT lebelcatherine structuralconnectomedifferencesinpediatricmildtraumaticbrainandorthopedicinjury AT structuralconnectomedifferencesinpediatricmildtraumaticbrainandorthopedicinjury |