JIB-04 Has Broad-Spectrum Antiviral Activity and Inhibits SARS-CoV-2 Replication and Coronavirus Pathogenesis

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Pathogenic coronaviruses are a major threat to global public health. Here, using a recombinant reporter virus-based compound screening approach, we identified small-molecule inhibitors that potently block the replication of severe acute respiratory syndrome virus 2 (SARS-CoV-2). Among them, JIB-04 i...

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Detalles Bibliográficos
Autores principales: Son, Juhee, Huang, Shimeng, Zeng, Qiru, Bricker, Traci L., Case, James Brett, Zhou, Jinzhu, Zang, Ruochen, Liu, Zhuoming, Chang, Xinjian, Darling, Tamarand L., Xu, Jian, Harastani, Houda H., Chen, Lu, Gomez Castro, Maria Florencia, Zhao, Yongxiang, Kohio, Hinissan P., Hou, Gaopeng, Fan, Baochao, Niu, Beibei, Guo, Rongli, Rothlauf, Paul W., Bailey, Adam L., Wang, Xin, Shi, Pei-Yong, Martinez, Elisabeth D., Brody, Steven L., Whelan, Sean P. J., Diamond, Michael S., Boon, Adrianus C. M., Li, Bin, Ding, Siyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764536/
https://www.ncbi.nlm.nih.gov/pubmed/35038906
http://dx.doi.org/10.1128/mbio.03377-21
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