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CRISPR Interference Reveals That All-Trans-Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A

Macrophages are a protective replicative niche for Mycobacterium tuberculosis (Mtb) but can kill the infecting bacterium when appropriately activated. To identify mechanisms of clearance, we compared levels of bacterial restriction by human macrophages after treatment with 26 compounds, including so...

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Detalles Bibliográficos
Autores principales:	Babunovic, Gregory H., DeJesus, Michael A., Bosch, Barbara, Chase, Michael R., Barbier, Thibault, Dickey, Amy K., Bryson, Bryan D., Rock, Jeremy M., Fortune, Sarah M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764544/ https://www.ncbi.nlm.nih.gov/pubmed/35038923 http://dx.doi.org/10.1128/mbio.03683-21

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