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Fate of hematopoietic stem cells determined by Notch1 signaling (Review)

Regulation of the fate of hematopoietic stem cells (HSCs), including silencing, self-renewal or differentiation into blood line cells, is crucial to maintain the homeostasis of the human blood system and prevent leukemia. Notch1, a key receptor in the Notch signaling pathway, plays an important regu...

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Autores principales: Ge, Yidong, Wang, Jie, Zhang, Hui, Li, Jinyun, Ye, Meng, Jin, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764575/
https://www.ncbi.nlm.nih.gov/pubmed/35069851
http://dx.doi.org/10.3892/etm.2021.11093
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author Ge, Yidong
Wang, Jie
Zhang, Hui
Li, Jinyun
Ye, Meng
Jin, Xiaofeng
author_facet Ge, Yidong
Wang, Jie
Zhang, Hui
Li, Jinyun
Ye, Meng
Jin, Xiaofeng
author_sort Ge, Yidong
collection PubMed
description Regulation of the fate of hematopoietic stem cells (HSCs), including silencing, self-renewal or differentiation into blood line cells, is crucial to maintain the homeostasis of the human blood system and prevent leukemia. Notch1, a key receptor in the Notch signaling pathway, plays an important regulatory role in these properties of HSCs, particularly in the maintenance of the stemness of HSCs. In recent decades, the ubiquitination modification of Notch1 has been gradually revealed, and also demonstrated to affect the proliferation and differentiation of HSCs. Therefore, a detailed elucidation of Notch1 and its ubiquitination modification may help to improve understanding of the maintenance of HSC properties and the pathogenesis of leukemia. In addition, it may aid in identifying potential therapeutic targets for specific leukemias and provide potential prognostic indicators for HSC transplantation (HSCT). In the present review, the association between Notch1 and HSCs and the link between the ubiquitination modification of Notch1 and HSCs were described. In addition, the association between abnormal HSCs mediated by Notch1 or ubiquitinated Notch1and T-cell acute lymphoblastic leukemia (T-ALL) was also examined, which provides a promising direction for clinical application.
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spelling pubmed-87645752022-01-20 Fate of hematopoietic stem cells determined by Notch1 signaling (Review) Ge, Yidong Wang, Jie Zhang, Hui Li, Jinyun Ye, Meng Jin, Xiaofeng Exp Ther Med Review Regulation of the fate of hematopoietic stem cells (HSCs), including silencing, self-renewal or differentiation into blood line cells, is crucial to maintain the homeostasis of the human blood system and prevent leukemia. Notch1, a key receptor in the Notch signaling pathway, plays an important regulatory role in these properties of HSCs, particularly in the maintenance of the stemness of HSCs. In recent decades, the ubiquitination modification of Notch1 has been gradually revealed, and also demonstrated to affect the proliferation and differentiation of HSCs. Therefore, a detailed elucidation of Notch1 and its ubiquitination modification may help to improve understanding of the maintenance of HSC properties and the pathogenesis of leukemia. In addition, it may aid in identifying potential therapeutic targets for specific leukemias and provide potential prognostic indicators for HSC transplantation (HSCT). In the present review, the association between Notch1 and HSCs and the link between the ubiquitination modification of Notch1 and HSCs were described. In addition, the association between abnormal HSCs mediated by Notch1 or ubiquitinated Notch1and T-cell acute lymphoblastic leukemia (T-ALL) was also examined, which provides a promising direction for clinical application. D.A. Spandidos 2022-02 2021-12-27 /pmc/articles/PMC8764575/ /pubmed/35069851 http://dx.doi.org/10.3892/etm.2021.11093 Text en Copyright: © Ge et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Ge, Yidong
Wang, Jie
Zhang, Hui
Li, Jinyun
Ye, Meng
Jin, Xiaofeng
Fate of hematopoietic stem cells determined by Notch1 signaling (Review)
title Fate of hematopoietic stem cells determined by Notch1 signaling (Review)
title_full Fate of hematopoietic stem cells determined by Notch1 signaling (Review)
title_fullStr Fate of hematopoietic stem cells determined by Notch1 signaling (Review)
title_full_unstemmed Fate of hematopoietic stem cells determined by Notch1 signaling (Review)
title_short Fate of hematopoietic stem cells determined by Notch1 signaling (Review)
title_sort fate of hematopoietic stem cells determined by notch1 signaling (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764575/
https://www.ncbi.nlm.nih.gov/pubmed/35069851
http://dx.doi.org/10.3892/etm.2021.11093
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