Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma

While there is extensive evidence for genetic variation as a basis for treatment resistance, other sources of variation result from cellular plasticity. Using multiple myeloma as an example of an incurable lymphoid malignancy, we show how cancer cells modulate lineage restriction, adapt their enhanc...

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Detalles Bibliográficos
Autores principales: Frede, Julia, Anand, Praveen, Sotudeh, Noori, Pinto, Ricardo A., Nair, Monica S., Stuart, Hannah, Yee, Andrew J., Vijaykumar, Tushara, Waldschmidt, Johannes M., Potdar, Sayalee, Kloeber, Jake A., Kokkalis, Antonis, Dimitrova, Valeriya, Mann, Mason, Laubach, Jacob P., Richardson, Paul G., Anderson, Kenneth C., Raje, Noopur S., Knoechel, Birgit, Lohr, Jens G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764878/
https://www.ncbi.nlm.nih.gov/pubmed/34675390
http://dx.doi.org/10.1038/s41556-021-00766-y

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